The Bioanalysis Glossary


122. dilution The procedure of adding control matrix to quality control or incurred samples. This process is used to bring incurred samples with concentrations above the upper limit of quantification (ULOQ) into the calibration curve range for analysis.


123. dilutional linearity Demonstration that spiked quality control samples with concentrations exceeding the upper limit of the validated concentration range can be shown to give the same concentration (within acceptable accuracy and precision) when assayed at multiple dilutions to give results in the validated concentration range.


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124. dilution QC sample Samples of control matrix spiked with analyte to which additional control matrix is added prior to analysis to bring sample concentration into calibration range. Used to evaluate the acceptability of incurred samples analyzed after dilution.


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Bioanalysis (2020) 12(21) Suppl. 1


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