Definitions 9.


acid dissociation Sample pretreatment step using a decrease in pH to dissociate an analyte from a protein (e.g., drug–antidrug antibody [ADA] complexes), and is often used in conjunction with various immunoassay/immunoextraction method formats to improve the recovery and reliability of analyte measurement.


10. ADME Commonly used acronym in pharmacology and pharmacokinetics, which stands for absorption, distribution, metabolism and excretion. ADME can also be applied in conjunction with toxicology (ADMET).


11. adverse event Any untoward medical occurrence in a patient or clinical trial subject that has been exposed to a medicinal product, and which may or may not have a causal relationship with the treatment.


12. affinity Ability of a drug to bind to its biological target, often described numerically as ka


constant of the drug–receptor complex.


, the reciprocal of the equilibrium dissociation


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