Definitions


273. metabolite features Peaks with a unique mass-to-charge ratio or deconvoluted as a cluster of different mass spectrometry (MS) species (adducts, neutral losses) corresponding to a unique mass-to-charge ratio, a unique retention time and with an intensity value (or area under the peak).


274. metabolite profiling The measurement of all


low-molecular-weight metabolites and their intermediates in a biological system. Also see ‘Metabolomics’.


275. metabolites in safety testing (MIST) The detection, confirmation and comparison of the exposure of drug metabolites observed in human clinical trials with those observed in animal studies. Used to establish the safety of the human metabolites through demonstrating adequate exposure in animal species.


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