The Bioanalysis Glossary


425. sensitivity The lowest analyte concentration that can be measured above the noise with acceptable accuracy and precision (i.e., lower limit of quantification [LLOQ]). An alternative and statistical definition is the slope of the concentration-response calibration curve at any given point on the curve.


426. serum The liquid that is obtained after clotting of the blood and subsequent centrifugation.


427. shotgun proteomics Identification of proteins in the sample is based on a preliminary enzymatic digestion of the mixture followed by HPLC–MS/MS characterization of the resulting peptides.


428. side effect Any adverse consequence resulting from the use of a medicinal product.


429. signal-to-noise ratio (S/N) The ratio of actual response signal to the differentiated background signal for a given detector.


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Bioanalysis (2020) 12(21) Suppl. 1


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