The Bioanalysis Glossary


99. coefficient of variation (CV) A statistical term used for the measurement of precision. It is equivalent to relative standard deviation (RSD) and is calculated as standard deviation/mean, or %CV as CV × 100.


100. collision-induced dissociation/collision-activated


dissociation A technique in mass spectrometry where molecular ions are accelerated through the application of electrical potential and allowed to collide with neutral gas molecules to facilitate fragmentation.


101. comedication stability The process of assessing the stability of an analyte in the presence of a compound that is administered together with the analyte. Such assessments have been requested by regulatory agencies when a fixed dose combination (FDC) dosage form is being administered. In these cases, the matrix stability of one drug must be determined in the presence of the other drug in the combination at a ratio indicative of the FDC.


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Bioanalysis (2020) 12(21) Suppl. 1


future science group


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