231. investigator’s brochure (IB) A compilation of the clinical and nonclinical data on the investigational product(s) with analysis and discussion that is relevant to the study of the investigational product(s) in human subjects.
232. ion-exchange chromatography Chromatographic separation mode based on manipulation of charge and electrostatic interactions between the analytes, mobile phase and stationary phase.
233. ion-mobility spectrometry Technique used in conjunction with mass spectrometry to separate ions based on relative mobilities in a drift cell with electric field and carrier buffer gas. The mobility of an ion depends on cross- sectional area, shape and charge.
234. ion-pairing chromatography A chromatographic method that utilizes additives, typically in a mobile phase, that undergo electrostatic binding to oppositely charged analytes. A frequent goal of ion-pairing chromatography in reversed phase systems is to reduce or eliminate adverse peak shapes, caused by a positively charged analyte interacting with silanols groups on silica-based columns.
