227. intra-assay precision Precision as it pertains to bioanalytical validation, typically calculated as the %CV or RSE (relative standard error) from the analysis of six replicates within a single analytical run.
228. intravascular administration All routes of administration where the drug is directly introduced into the blood stream. IV refers to intravenous administration. PO (per OS) refers to oral administration. Combined IV and PO experiments provide the pharmacokinetic calculations for oral bioavailability.
229. intrinsic clearance Theoretical unrestricted maximum clearance of unbound drug by an elimination organ.
230. Investigational New Drug (IND) application The means by which a pharmaceutical company obtains permission to ship an experimental drug across state lines (usually to clinical investigators) before a marketing application (NDA or New Drug Application) for the drug has been approved. The US FDA reviews the IND application for safety and/or efficacy to assure that research subjects will not be subjected to unreasonable risk.
