The Bioanalysis Glossary


344. pharmacokinetics (PK) The kinetics of drug absorption, distribution and elimination (i.e., excretion and metabolism). Distribution occurs not only to site of action, but to multiple other tissues in the body.


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345. pharmacometabonomics/pharmacometabolomics Analysis of endogenous metabolites in bodily fluids used to predict or evaluate the metabolism of


pharmaceutical drugs,


and to understand the pharmaco kinetic profile of a drug. Alternatively, it is applied to measure metabolite levels following the administration of a pharmaceutical drug, in order to monitor the effects of the compound on certain biochemical pathways.


346. Phase I trial First in-human clinical trial phase to evaluate the safety and toxicity of a new treatment.


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Bioanalysis (2020) 12(21) Suppl. 1


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