2D chromatography Simplest form of multidimensional chromatography, involving two distinct chromatographic systems interfaced such that heart-cuts (also see ‘Heartcutting’) from the first are injected into the second. The result is combined chromatography that involves and benefits from the selectivities of both chromatographic dimensions, often with increased sensitivity as well as resolving power.
2.
abbreviated new drug application (ANDA) Request to the US Food and Drug Administration (FDA) for approval of a generic drug.
3.
absolute bioavailability Extent of unchanged drug absorbed upon extravascular administration in comparison to the dose administered intravascularly (i.e., percentage of drug absorbed unchanged).
4. absorption The in vivo process of uptake of a drug post-administration.
