214. incurred sample Study sample from human or animal subjects, pre- and usually post-administration of
therapeutic drugs. Study subjects may
either be human, for clinical studies, or non-human, for preclinical and safety studies.
215. incurred sample reanalysis Repeated measurement of analyte concentration from a portion of the incurred study samples from dosed subjects to evaluate the reliability of the original results and the method itself.
216. in-source fragmentation In LC–MS, fragmentation of a molecule or further fragmentation of a molecular ion in the mass spectrometer vacuum interface region between the source and low-pressure analytical segment, usually caused by collisions occurring during acceleration from the source probe electrode tip to the lens or cone at the head of the mass filter rail under reduced pressure but in the presence of nitrogen curtain or shield gas.
