283. method validation A comprehensive set of documented experiments to investigate whether an analytical method is functioning according to predefined acceptance criteria. For regulated bioanalysis, criteria should be in compliance with guidelines published by regulatory authorities.
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284. micelle An aggregate of molecules in a colloidal solution. For example, a liposomal suspension.
285. micellar electrokinetic chromatography Separation technique hybrid of electrophoresis and chromatography where a surfactant, generally ionic (e.g., sodium dodecyl sulfate [SDS]), is added to the separation buffer at a higher
concentration than its critical micelle concentration (CMC). During migration micelles act as a pseudo-stationary phase allowing solute partition through both hydrophobic and electrostatic interactions and simultaneously to electrophoretic separation.
