The Bioanalysis Glossary


311. non-zero calibrator A calibrator to which the IS is added.


312. nonspecific adsorption/binding Undesirable phenomenon comprising the adsorption of analytes to the interior surfaces of vessels containing the solution. Typically addressed by the use of a solvent composition within which the given analyte has increased or free solubility at the appropriate concentrations, and/or the use of vessels of different material or surface chemistry.


313. nontargeted analysis Analysis of the composition of a complex sample without applying predefined selection criteria, with the aim to identify previously unknown sample components. The opposite of selective (targeted) analysis in which specific data are generated.


314. normal-phase chromatography A mode of chromatography employing a polar stationary phase (e.g., native silica) and a nonpolar mobile phase. Lipophilic analytes have limited affinity for the stationary phase and are eluted first, while hydrophilic analytes tend to adsorb to the stationary phase and are eluted by increasing the polarity of the mobile phase.


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Bioanalysis (2020) 12(21) Suppl. 1


future science group


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