modification of lead compounds, designed to enhance their potency, selectivity, pharmacokinetic or ADMET properties, with the goal of producing a viable drug candidate, suitable for formal development.
248. least squares A statistical method of determining a regression equation which best describes the relationship between two variables.
249. ligand-binding assay (LBA) Qualitative or quantitative method based on the binding of ligand molecules to antibodies or receptors, typically used for biomolecules where the reliance is on highly specific epitope– paratope interactions between antigen and antibody.
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250. limit of detection (LOD) The lowest concentration of an analyte that a bioanalytical procedure can reliably differentiate from background noise (e.g., ‘detected and not quantified’).
