Equations


5. matrix effects Internal standard (IS) normalized matrix effect = mean of (peak area ratio in presence of matrix, where both analyte and internal standard are added to extracts of control matrix)/(peak area ratio of analyte and internal standard in absence of matrix)


Note: a ratio of means is different from a mean of ratios


%bias = mean measured conc. – nominal conc. × 100 nominal conc.


%CV = standard deviation (SD) × 100 mean measured conc.


%Recovery = 100 × mean peak area ratio (extracted samples containing analyte to which internal standard is added post- extraction)/peak area ratio (post-extraction-spiked samples, where both analyte and internal standard are added to extracts of control matrix)


Note: a ratio of means is different from a mean of ratios


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