347. Phase II trial Clinical trial evaluating the efficacy and safety of a new treatment. Note 1: Can be divided into phase IIa and phase IIb to evaluate dosing requirements and clinical efficacy of a drug, respectively.
348. Phase III trial Clinical trial to evaluate thee efficacy and safety of a new treatment in a large number of patients and to compare it with the current standard-of-care treatment.
349. phosphodiester Pertains to the chemical nature of an inter-nucleotide linkage, such as in an oligonucleotide. A phosphodiester linkage is formed when the acidic hydroxyl group on the phosphate moiety attached to the 5’ carbon on a nucleotide sugar unit undergoes a condensation reaction with the hydroxyl group on the 3’ carbon on the sugar of the adjacent nucleotide.
350. phospholipids A class of lipids that are the major components of cell membrane bilayers. In bioanalysis, these have been identified as one of the major endogenous components that can cause matrix effects in electrospray ionization (ESI).
