The Bioanalysis Glossary


polymerase chain reaction (PCR), 115


population-specific cut point, 115 post-column infusion, 115 post-translational modification (PTM), 115 PrD-LC–MS, 116 PrD-LC–MS-IC, 116 PrD-LC–MS-SC, 116 PrD-LC–MS-IC-SC, 117 precision, 117 preclinical study, 117 precursor ion, 118


predictive metabolomics, 118 pre-dose sample, 118


preventative maintenance (PM), 118


principal components analysis (PCA), 118


principal investigator, 119 processed sample, 119 processing batch, 119 prodrug, 119 product ion, 120 protein binding, 120 protein precipitation, 120 protein therapeutics, 121 proteomics, 121 protocol, 121


protocol amendment, 121 protocol deviation, 122 proxy matrix, 122 prozone, 122 qualified assay, 122 quality assurance, 123 quality control, 123


quality control sample (QC), 123 quantification range, 123 radioimmunoassay (RIA), 124 raw data, 124


reactive metabolite, 126 reanalysis, 126


recovery (extraction), 126 reference standard, 126 regulated bioanalysis, 127 regulatory validation, 127 reintegration, 127 relative bioavailability, 127 relative error, 128


relative standard deviation (RSD), 128


repeatability, 128 reproducibility, 128 resolution, 128 response function, 129 retention time (RT), 129 reversed-phase chromatography, 129


risk-based approach, 130 robustness, 130 ruggedness, 130 r-squared, 130


salting out assisted liquid–liquid extraction (SALLE), 131 sample, 131 sample diluent, 131 sample pretreatment, 131 scientific validation, 132 selected reaction monitoring (SRM), 132 selectivity, 132 sensitivity, 134


164


Bioanalysis (2020) 12(21) Suppl. 1


future science group


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