90 ANTI-AGEING
120 100 80 60 40 20 0
0 4 8 Time (Weeks) Figure 8: Formulation stability investigation test of AC-HPR-S10 with retinol (in DMI)
Improve skin radiance As seen in Figure 11, HPR Essential Lotion improves skin radiance, with statistics showing a 14.2% increase in overall skin radiance and firmer skin.
Brighten skin As seen in Figure 12, HPR Essential Lotion brightens the skin tone and the statistics show that the overall skin brightness has increased by 1.3%. It is predicted that better results will be obtained if the duration of use is extended.
Conclusion HPR (Hydroxy pinacolone retinoate), as the third generation of Vitamin A for cosmetic use, has excellent stability, higher safety, and excellent efficacy compared with other first and second generation Vitamin A. As a new generation of Vitamin A derivatives,
it has a great market prospect in the application of cosmetic industry. Aneco has developed different specifications (oil-soluble and water-soluble specifications) to meet different application requirements. Meanwhile, the mechanism behind its
advantages as a Vitamin A active with the above advantages is being further studied.
References 1. Blomhoff R, Blomhoff HK. Overview of retinoid metabolism and function. J. Neurobiol. 2006; 66(7):606-630
2. Truchuelo MT, Jiménez N, Mavura D, Jaén P. Assessment of the Efficacy and Safety of a Combination of 2 Topical Retinoids (RetinSphere) in Maintaining Post-Treatment Response of Acne to Oral Isotretinoin. Actas Dermo-Sifiliográficas. 2015; 106(2):126–132
3. Chen X et al. Progress of the protective effect of all-trans retinoic acid on foot cell injury. Chinese Journal of Contemporary Pediatrics. 2017; 19 (6): 719-723
4. Balmer JE, Blomhoff R. Gene expression regulation by retinoic acid. J. Lipid Res. 2002; 43(11):1773-1808
5. Kishimoto M, Fujiki R, Takezawa S, Sasaki Y, Nakamura T, Yamaoka K, Kitagawa H, Kato S. Nuclear Receptor Mediated Gene
PERSONAL CARE November 2024 Figure 11: 14.2% increase in overall skin radiance Figure 12: Overall skin brightness increased by 1.3%
www.personalcaremagazine.com PC
Figure 9: Wrinkle reduction around the eyes of 39%
9 8.6
8.5 8
7.53
7.5 7
6.5 D0 D14 Time D28 8.22
Figure 10: Reduction in the area of spots of 43.6%
69.3 69
68.7 68.4 68.1 67.8 67.5
68.23 69.1 68.93
Regulation through Chromatin Remodeling and Histone Modifications. Endocr. J. 2006; 53(2):157-172
6. McCaffery PJ, Adams J, Maden M, Rosa- Molinar E. Too much of a good thing: retinoic acid as an endogenous regulator of neural differentiation and exogenous teratogen. Eur. J. Neurosci. 2003; 18(3): 457-472.
7. Bastien J, Rochette-Egly C. Nuclear retinoid
14 12 10 8 6 4 2 0
12.36 9.79 7.54
receptors and the transcription of retinoid- target genes. Gene. 2004; 3281-16
8. McGrane MM. Vitamin A regulation of gene expression: molecular mechanism of a prototype gene. The Journal of Nutritional Biochemistry. 2007; 18(8):497-508
9. Rakuša ZT, Škufca P, Kristl A, Roškar R. Retinoids stability and degradation kinetics in commercial cosmetic products. Journal of Cosmetic Dermatology. 2020; P1-0189
D0 D14 Time D28
16 14 12 10 8 6 4 2 0
14.39 10.13 8.11 AC-HPR-S10■ Retinol in DMI■
12
16
D0
D14 Time
D28
D0
D14 Time
D28
Residual Rate (%)
Skin gloss
Canthus Wrinkles
Skin Brightness-L value
Spot Area
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