ANTI-AGEING


Forty-eight hour patch test A 48-hour patch test was carried out according to the code of practice for cosmetic safety technology (2015 edition) showing the number of cases with adverse skin reactions. From this 48-hour patch test (data not


shown), it was seen that the results in the test area where the test samples were located were 29 negative reactions and 3 suspicious reactions out of 32 volunteers. According to the determination criteria, it was assessed that 0.5% HPR solution (oil base containing 0.5% pure HPR) is expected to have no adverse reaction on human skin.


Efficacy experiments Vitamin A actives can accelerate skin metabolism, stimulate collagen, glycosaminoglycan production, reduce skin roughness; inhibit tyrosinase, reduce pigmentation, the efficacy of the main in the anti-ageing, brightening, firming, etc., for the treatment of acne also has some effect. For this purpose, we conducted a clinical


trial and formulated HPR Extract Lotion (0.2% HPR), which was used by volunteers for 28 days,


120 100 80 60 40 20 0


80°C (0h) 80°C (2h) Figure 7: Heat stabilization investigation test of AC-HPR-S10 with retinol (in DMI)


TABLE 2: SAMPLE OD VALUE (MEAN±SD) Group (µG/mL)


NC SC


1000


316.46 31.65 3.16


0.316 0.0316 0.00316


89


-Irr


0.8114 ± 0.0713 0.7473 ± 0.0833 0.5543 ± 0.0576 0.6763 ± 0.0413 0.6867 ± 0.0600 0.7577 ± 0.0889 0.7023 ± 0.0837 0.6948 ± 0.0267 0.8344 ± 0.0499


once in the morning and once in the evening, and obtained the following relevant data.


Reduce wrinkles As seen in Figure 9, HPR Essential Lotion fights fine lines and wrinkles, and statistics show that it reduces wrinkles around the eyes by 39%.


Spot-fading As seen in Figure 10, HPR Essential Emulsion lightens spots and statistics show that it reduces the area of spots by 43.6%.


AC-HPR-S10■ Retinol in DMI■


120 100 80 60 40 20 0


+Irr


0.7081 ± 0.0285 0.7067 ± 0.0265 0.5789 ± 0.0499 0.6337 ± 0.0718 0.6644 ± 0.0180 0.6741 ± 0.0392 0.6372 ± 0.0523 0.6050 ± 0.0596 0.7020 ± 0.0607


TABLE 3: PHOTOTOXICITY TEST RESULTS IC50


-Irr +Irr


MPE PIF


Prediction


>1000µg/mL >1000µg/mL -0.0380 1.000


No Phototoxicity AC-HPR-S10■ Retinol in DMI■


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November 2024 PERSONAL CARE


Residual Rate (%)


Residual Rate (%)


50°C (0h) 50°C (5h) 50°C (1d) 50°C (3d) 50°C (6d) 50°C (9d)


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