HAIR CARE
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Control ■ 1% Oat Peptide Powder ■ 0 -50
-100 -150
-200 -250
After 30 Days After 90 Days After 120 Days -90%* -20%* -111%* Placebo ■ 1% Oat Peptide Powder ■
Figure 4: Hair fall reduction over 120 days with OPP treatment. T-test, Significant: *=p<0.05 (95%), #=p<0.1 (90%)
The number of hairs falling out during hair
combing, under standardised conditions was determined. The participants attended the assessment without having washed their hair for at least 48 hours before and without having combed their hair at least 24 hours before. This protocol ensures that the hairs near
the end of telogen phase are maintained and avoids artificial reduction in the percentage of hairs in telogen phase. Each participants’ hair was combed by the technician according to a standard protocol and the hair fall was collected for later counting. A significant decrease in hair fall is observed upon 1% OPP treatment (Figure 4). When compared to placebo, 1% OPP results in significantly reduced hair fall after 30, 90 and 120 days. The efficacy of OPP treatment shows a significant improvement in hair fall reduction. The shirt term effects (1 month), initially are due to OPP impact on reducing the shedding of hairs in the telogen phase and promoting the anagen phase. However, by the 4th month, many of the
hairs that entered the telogen phase at the start of the treatment would have naturally fallen out, completing their cycle. As a result, the observed reduction in hair fall is less pronounced because the hair growth cycle is dynamic and new hairs would be entering the telogen phase naturally, leading to some level of hair shedding. This natural cycle of hair shedding and regrowth leads to a stabilisation of the treatment’s impact on hair fall reduction. OPP significantly reduces hair fall by stimulating hair follicles, resulting in fuller- looking hair with minimised shedding.
Boosting hair density with OPP Reduced hair fall activity preserves existing follicles, facilitating OPP’s next role in enhancing hair density. An addition study was carried out using the same in vivo study protocol as described in the previous study (same panel and product treatment). Scalp hair density was evaluated by TrichoScan micro camera. Hair density is defined as the number of hairs present in a unit of area (cm2
). A significant increase in hair density is
observed upon 1% OPP treatment (Figure 5). When compared to placebo, 1% OPP results in
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20 15 10 5 0
-5 After 30 Days After 90 Days After 120 Days
Figure 5: Hair density increase over 120 days with OPP treatment. T-test, Significant: ****=p<0.0001, *=p<0.05 (95%)
significant increase in hair density after 30, 90 and 120 days, promoting a fuller, denser and healthier-looking hair.
Applications of OPP in hair care OPP is suitable for applications such as anti-ageing scalp serum, densifying scalp treatment, youth revitalising shampoo, anti-hair fall conditioner. Table 1 gives an example of application OPP in an anti-ageing scalp serum. This formulation demonstrates the exciting opportunities for this natural, high purity active providing healthy, vibrant hair with boosted volume and vitality.
Conclusion With age, collagen and elastin production naturally decrease, which can lead to hair thinning and hair fall. As collagen levels decline, blood flow to the scalp diminishes, reducing the supply of essential nutrients and oxygen to the hair follicles.9
This contributes to the
shortening of the anagen (growth) phase and the miniaturisation of hair follicles. Additionally, reduced elastin makes the
scalp less resilient, further impacting follicle health. Combined with hormonal changes, such as increased DHT levels, these factors lead to an increase in hair fall and a decrease in hair density over time. EcoPep presents a holistic solution to
combat age-related hair changes. OPP, natural high purity peptide powder, enhances the
TABLE 1: ANTI-AGEING SCALP SERUM WITH HIGH PURITY NATURAL PEPTIDE
Phase Ingredients Nomenclature Aqua
A B C
Hydroxyethylcellulose Aqua, Sodium phytate Propanediol Xanthan Gum Parfum
D Benzoic Acid, benzyl Alcohol, Avena Sativa (Oat) Peptide
Polysorbate 20 Caprylyl Glycol
E F
Caramel (colorant) G Aqua, Sodium Hydroxide
% w/w 91.745 0.500 0.050 3.000 0.300 0.250 2.500
1.000 0.500
0.035 0.120
structural integrity of the scalp by promoting extracellular matrix (ECM) with collagen and elastin boost. This fortified ECM with OPP and the downregulation of steroid 5a-reductase 1 and steroid 5a-reductase 3 support the integrity of hair follicles, reduce hair fall and enhance the production of dense, healthy hair. EcoPep targets key age-related scalp and
haircare concerns by optimising the natural functions and health of the scalp and hair, boosting vibrance and vitality.
PC
References 1. Stough D, Stenn K, Haber R, Parsley WM, Vogel JE, Whiting DA et al. Psychological effect, pathophysiology, and management of androgenetic alopecia in men. Mayo Clinic Proceedings. 2005;80(10):1316-1322
2. Narang T, Bhattacharjee R. Hair loss and nutrition: A comprehensive review. J. Med. Nutr. Nutraceut. 2013;2(1):22-29
3. Lintner K, Peschard O. Biologically active peptides: From a laboratory bench curiosity to a functional skin care product. Int. J. Cosmet. Sci. 2000;22(3):207-218
4. Bolke L, Schlippe G, Gerß J, Voss W. A collagen supplement improves skin hydration, elasticity, roughness, and density: Results of a randomized, placebo-controlled, blind study. J. Med. Food. 2019;22(2):103-109
5. Bailey AJ, Paul RG. Collagen and elastin in human skin: Their structure and function in health and disease. J. Am. Acad. Dermatol. 1998;39(2 Pt 1):241-262
6. Inui S, Itami S. Androgen actions on human hair follicles: Perspectives. Exp. Dermatol. 2013;22(3):168-171
7. Hamilton JB. Male hormone stimulation is prerequisite and an incitant in common baldness. Am. J. Anat. 1942;71:451-480
8. Nestor MS, Ablon G, Gade A, Han H, Fischer DL. Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics. J. Cosmet. Dermatol. 2021;20(12):3759-3781
9. Varani J, Dame MK, Rittie L, Fligiel SE, Kang S, Fisher GJ et al. Decreased collagen production in chronologically aged skin: Roles of age- dependent alteration in fibroblast function and defective mechanical stimulation. Am. J. Pathol. 2006;168(6):1861-1868
November 2024 PERSONAL CARE 8x**** 22x****
12x*
Variation of Number of Hairs Falling out From Day 0 (%)
Variation of Hair Density from Day 0 (%)
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