SKIN BRIGHTENING
Ticking the sustainability box Nanoformulations of ellagic acid ticks the sustainability box since it comprises edible, natural, and biodegradable materials. Encapsulated in liposomes, ellagic acid holds excellent promise as a skin-brightening agent and potent anti-oxidant with sustainable credentials. Additionally, modern delivery systems use
safe nano-ingredients such as nano-cellulose derivatives instead of synthetic nano- polymers or implement green chemistry with less hazardous and renewable reagents and solvents.12
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alleviates skin wrinkle and inflammation induced by UV-B irradiation. Experimental Dermatology. August 2010; volume 19, issue 8, p.182-190
8. Sarkar R, Chugh S, Garg VK. Newer and upcoming therapies for melasma. Indian Journal of Dermatology, Venereology, and Leprology. 2012:78:4;417-428
However, further research is needed
to address concerns about the safety and sustainability of oral or internally administered products.12
Conclusion The approach to skin lightening has expanded significantly. Nanotechnology will continue to pave the way for developing effective and sustainable products in cosmetics. Formulations will become more optimized, with improved bioavailability and higher absorption of active ingredients. Simply put, the future looks bright for the skin-brightening industry. While the environmental onslaught may be leaving its mark on human skin, there is liposomal ellagic acid for those caring to look on the bright side.
References 1. Ceci C et al. Strategies to improve ellagic acid bioavailability: from natural or semisynthetic derivatives to nanotechnological approaches based on innovative carriers. Nanotechnology. 2020; 31, 38200
2. Junyaprasert VP, Singhsa P, Jintapattanakit A. Influence of chemical penetration enhancers on skin permeability of ellagic acid-loaded niosomes. Asian Journal of Pharmaceutical Sciences. April 2013; volume 8, issue 2, p.110-117
9. Kim YH, Kim KH, Han CS, Yang HC, Park SH, Jang HI, Kim JW, Choi YS, Lee NH. Anti-wrinkle activity of Platycarya strobilacea extract and its application as a cosmeceutical ingredient. J. Cosmet. Sci. 2010; May-Jun;61(3):211-24
10. Draelos Z, Dahl A, Yatskayer M, Chen N, Krol Y, Oresajo C. Dyspigmentation, skin physiology, and a novel approach to skin lightening. Journal of Cosmetic Dermatology. December 2013; volume 12, issue 4, pages 247-253
3. Junyaprasert VP, Singhsa P, Suksiriworapong J, Chantasart D. Physicochemical properties and skin permeation of Span 60/Tween 60 niosomes of ellagic acid. International Journal of Pharmaceutics. 28 February 2012; volume 423, issue 2, p.303-311
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4. Junyaprasert VP, Singhsa P, Jintapattanakit A. Influence of chemical penetration enhancers on skin permeability of ellagic acid-loaded niosomes. Asian Journal of Pharmaceutical Sciences. April 2013; volume 8, issue 2, p. 110- 117
5. Liu J-K. Natural products in cosmetics. Natural Products and Bioprospecting. 28 November 2022, volume 12
6. Abd-Elghany AA, Mohamad EA. Chitosan- Coated Niosomes Loaded with Ellagic Acid Present Antiaging Activity in a Skin Cell Line. ACS Omega. 2023; May 16; 8(19): 16620– 16629
7. Bae J-Y, Choi J-S, Kang S-W, Lee Y-J, Park J, Kang Y-H. Dietary compound ellagic acid
11. Suwannarat K, Kittiphinitnunta K, Ongwisut P, Bumrungthai S, Ngawhirunpat T, Charoenputtakun P, Sila-On W. Role of Natural Antioxidants for Topical Applications: Properties Efficacy Safety and Novel Delivery Systems. Isan Journal of Pharmaceutical Sciences. February 2019; volume 15, issue 1, p. 21-48
12. Assali M, Abdel-Naser Z. Features, applications, and sustainability of lipid nanoparticles in cosmeceuticals. Saudi Pharmaceutical Journal. 2022; volume 30, issue 1, p. 53-65
13. Shimogaki, Tanaka, Tamai, Masuda (Yoshimasa Tanaka Life Science Research Center). In vitro and in vivo evaluation of ellagic acid on melanogenesis inhibition. International Journal of Cosmetic Science. August 2000; volume 22, issue 4, p. 239-315
14. Singh Hallan S, Sguizzato M, Pavoni G, Baldisserotto A, Drechsler M, Mariani P, Esposito E, Cortesi R. Ellagic Acid Containing Nanostructured Lipid Carriers for Topical Application: A Preliminary Study. Molecules. March 2020; volume 25, issue 6; p.1449
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