30 TRENDING TECHNOLOGIES
Plant exosomes for advanced skin, hair care
Òscar Expósito, Monika Buchholz, Alejandro Guirado, Ana Gallego, Maria Mas, Pau Riera, Daniel Luna, Sara Laplana, Tarik Ruiz, Sandra Ruiz, Marta Gibert - Vytrus Biotech
Exosomes, also known as ectosomes or small extracellular vesicles (sEVs), are lipid-bound vesicles naturally secreted by cells. These vesicles, which range from 30 to 500 nanometres in diameter, are crucial for intercellular communication as they transport bioactive molecules such as DNA, RNA, proteins, lipids, and cytokines. They play essential roles in gene regulation, immune response modulation, and tissue regeneration.1 Exosomes act as ‘natural biological
communicators’, carrying bioactive compounds that offer numerous benefits for the skin. Structurally similar to mammalian exosomes, these plant-derived vesicles facilitate effective cross-kingdom communication with human cells.
Their anti-inflammatory properties help
reduce redness and irritation, while their ability to modulate the immune system supports healing and skin homeostasis. Additionally, exosomes promote hydration and enhance the skin barrier by stimulating the production of extracellular matrix proteins like collagen and elastin. These combined effects result in improved skin texture, elasticity, and overall appearance.2-7 Exosomes used in cosmetics are derived
from various sources, including plants, animals, and synthetic processes. Although animal- derived exosomes are effective, they pose ethical concerns and stability issues.8 Synthetic exosomes lack the complexity
and bioactivity of their natural counterparts.9,10 In contrast, plant-derived exosomes offer a compelling alternative, combining high bioactivity with sustainability and ethical production.11,12 The effectiveness of exosomes in skincare depends on their ability to penetrate the skin barrier and deliver their cargo. Exosomes can enter cells through pathways like endocytosis, phagocytosis, and direct fusion. For transdermal delivery, they navigate through the skin via appendageal, intercellular, and transcellular routes. Their small size and fusogenic lipid membranes enable them to traverse the stratum corneum efficiently, reaching deeper skin layers to exert their therapeutic effects.13
Deeping into the potential of natural plant exosomes Plant-derived exosomes have several advantages over their mammalian
PERSONAL CARE November 2024
counterparts. They are more stable, easier to produce in large quantities, and free from ethical issues. Plant exosomes lack cholesterol, making them less immunogenic and suitable for sensitive skin. Their ability to encapsulate and protect bioactive compounds ensures sustained release and prolonged benefits. Additionally, plant exosomes can be customized to meet specific cosmetic needs, enhancing their versatility and effectiveness. However, producing plant-derived
exosomes for cosmetic use presents challenges. Extraction and purification can be complex and costly, with variability in yield and quality depending on plant sources and environmental conditions. Ensuring consistency and high yield requires advanced biotechnological solutions. Vytrus Biotech has tackled these challenges
by utilizing plant cell cultures to produce exosomes. This innovative method achieves high concentrations of bioactive exosomes, reaching billions per millilitre. By guiding plant cells to produce specific exosomes, Vytrus can tailor their properties to address various skin and hair concerns. This approach ensures stable, scalable, and customizable production, positioning plant cell culture-derived exosomes as a revolutionary advancement in the cosmetic industry.
Plant exosomes from Curcuma longa and Centella asiatica Cell Cultures Vytrus focuses on natural plant exosomes from
ABSTRACT
Natural plant exosomes are revolutionizing the field of skin and hair care with their extraordinary bioactive properties. These small extracellular vesicles (EVs), produced by plant cells, are rich in DNA, RNA, proteins, and lipids, and function as natural biological communicators. Unlike synthetic alternatives, plant exosomes provide a sustainable, natural, and highly effective solution that aligns with the increasing consumer demand for eco- friendly and effective beauty products. By enabling cross-kingdom communication, plant-derived exosomes are ushering in a new era of cosmetic innovation. They offer a unique and powerful approach to enhancing skin and hair health. The ability to customize and control the production of various types of exosomes highlights their vast potential, positioning natural plant exosomes as a groundbreaking advancement in the quest for advanced and sustainable cosmetic solutions. Vytrus Biotech has successfully created high- concentration plant-derived exosomes from Curcuma longa and Centella asiatica cell cultures. These exosomes significantly improve skin hydration, regeneration, and hair growth, while promoting anti-ageing, anti-inflammatory, and regenerative effects, making them essential components in modern cosmetic formulations.
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