60 ANTI-AGEING 0
-2 -4 -6 -8
-10 -12 -14 -16 -18
Control SCBE Figure 5: Mitochondrial activity; ***p<0.001
skin is forced into movements. Subjects had to frown their faces to reveal future or deeper wrinkles on crow’s feet area. Tension and visible wrinkles on the strongest facial expression (frowning) are compared to total measured surface of the face. SCBE induces a 16.4% decrease in skin
features density after 28 days of application, when placebo presented a unsignificant 2.8% increase on this item, over the same period. Skin facial density is visibly reduced by SCBE 1% (Figure 8).
Discussion and conclusion The sirtuin protein family is considered as a significant regulator of the physiological processes associated with ageing. SIRT has deacetylase, deacylase, and ADP- ribosyltransferase activity and modifies a variety of protein substrates, including chromatin components and regulatory proteins, and are involved in the regulation of different intracellular processes: cellular metabolism, mitochondrial functions, chromatin remodeling, response to oxidative stress and protein homeostasis.23
Changes
in the activity of sirtuins in human cells and model organisms are considered to be markers of ageing,24,25
as well as factors
Roughness (Ra) Variation vs D0 D14
1.5 0.5
-0.5 -1.5
-2.5 -3.5 -4.5
-1.2 1.1
D28 0.7
Schisandrin
affecting overall life expectancy such as energy homeostasis.26,27 Pathway analysis revealed that the
longevity regulation pathway and FOXO signaling pathway were regulated by the changes in genes and proteins to improve the lifespan.28
SIRT and mTORC1 are
youthfulness genes that induce autophagy by inhibiting mTOR. Thus, autophagy targeting is a potential future therapeutic strategy to potentially slow or reverse the ageing process, by preserving cell youthfulness through intracellular homeostasis and gene expression regulation.29,30 Thus, by acting on SIRT6 and downstream
processes, SCBE, an active ingredient based on schisandrin, a lignan extracted from the berries of Schisandra chinensis, is able to improve cell longevity by increasing mitochondria activity and autophagy. SCBE acts preventively on the skin’s longevity mechanisms, keeping skin resistant to the effects of time. With its multiple beneficial actions on
the markers of longevity, SCBE is a new- generation anti-ageing product. Beyond simply masking the effects of time, SCBE acts preventively to extend skin longevity and to preserve timeless beauty.
Wrinkle Count Variation vs D0 D14
D28 0.0
-2.0 -4.0 -6.0 -8.0
-4.1% * PERSONAL CARE November 2024
-10.0 -12.0
-2.0 -4.3 -5
-10 -15
-10.8% * Placebo ■ SCBE ■
Figure 7: Measure of skin roughness and wrinkle count variations at D14 and D28 compared to D0 after application of SCBE 1% or placebo; *p<0.05
-20 -16.4%* Placebo ■ SCBE ■
Figure 8: Skin density variations at D28 compared to D0 after application of SCBE 1% or placebo; *p<0.05
www.personalcaremagazine.com 0.1
+55% ***
Recovery time variation at D28 vs D0 0 ***
-2 -4 -6 -8
-10 -12 -14 -16 -18
-10.2
-16.8% *
Placebo ■ SCBE ■
Figure 6: Recovery time variation of air blown faces at D28 compared to D0; *p<0.05
References 1. Buettner D, Skemp S. Blue Zones: Lessons From the World’s Longest Lived. Am. J. Lifestyle Med. 2016;10(5):318-21
2. Appel LJ. Dietary patterns and longevity: expanding the blue zones. Circulation. 15 July 2008;118(3):214-5
3. Rollo CD, Marsh-Rollo SE, Boreham D, Lemon JA. Age-related expression of prominent regulatory elements in mouse brain: catastrophic decline of FOXO3a. GeroScience. August 2021;43(4):1935-46
4. Hao XD, Liu JX, Zhang JS. Longevity factor FOXO3a: A potential therapeutic target for age-related ocular diseases. Life Sci. 1 August 2024;350:122769
5. Pradhan R, Kumar R, Shekhar S, Rai N, Ambashtha A, Banerjee J et al. Longevity and healthy ageing genes FOXO3A and SIRT3: Serum protein marker and new road map to burst oxidative stress by Withania somnifera. Exp. Gerontol. September 2017;95:9-15
PC
6. Simon M, Yang J, Gigas J, Earley EJ, Hillpot E, Zhang L et al. A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. The EMBO Journal. 2 November 2022;41(21):e110393 7. Pan H, Guan D, Liu X, Li J, Wang L, Wu J et
Skin features density variation - D28 vs D0
5 0
2.8
% Change
Mitochondrial activity vs control (%)
% Change
% Change
% Change
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