TRENDING TECHNOLOGIES
properties and wrinkles (firmness and elasticity and clinical evaluation of wrinkle intensity), and facial complexion analysis using VISIA®, showing a holistic rejuvenating effect (wrinkles, texture, pores, visible spots, red areas, porphyrins). These studies demonstrate that the asset rejuvenates skin complexion, achieving a real appearance of up to four years of rejuvenation. Product’s ability to improve the
characteristics of facial skin under three types of lighting was tested. Measurement of six different parameters by VISIA® Canfield Imaging Systems: Visible Stains, Texture, Red Areas, Wrinkles, Porphyrins and Pores. Areas of application: face, measurements at 28-56 days; 2 daily applications by the volunteers (52-63-year-old women) of Centella Reversa, following the instructions of the study centre. Centella Reversa significantly reduced compared to baseline at 28 and 56 days all the parameters (Figure 7): wrinkles, texture, pores, visible stains, red areas and porphyrins.
Evaluation of the emotional hydration effect The active ingredient significantly increased the average cutaneous hydration rate at 28 days of treatment (p < 0.001): 13 % average from the start of the study, representing 4.3- fold higher than placebo, proving its effect as an emotional wellbeing manager. This is a very significant value considering that the study was performed on skin that was not selected for its level of dryness but for its level of psychosocial stress. The starting hydration was not dry or very dry and the study was conducted in the coldest winter period (January-February) in a geographic zone of rigorous Central European climate (Poland).
Conclusion Plant exosomes signify a remarkable leap forward in cosmetic science. By leveraging the inherent communicative abilities of exosomes, Vytrus Biotech has created a
EGF 5 µg/ml
33
A Global Hair Growth Activation* INITIAL TIME AFTER CL SECRETOME DENSITY ON HAIR
Tested in volunteers with alopecia
+17%
DENSITY ON EYELASHES
+57%
DENSITY ON EYEBROWS
+35% * After 150 days on hair and 120 days on eyelashes and eyebrows.
Figure 5: Global hair growth activation after 150 days treatment on hair (Microphotography; TrichoScan®) and 120 days treatment on eyelashes and eyebrows
suite of innovative products that provide substantial benefits for skin and hair care. The efficient delivery of bioactive compounds by plant exosomes to human cells establishes a foundation for natural, sustainable, and highly
TURMERIA ZEN™ 50 µg/ml
effective cosmetic solutions. Through the application of various
technological platforms, Vytrus has successfully stimulated the production of natural exosomes in plant cell cultures. Our research highlights that the cargo of these exosomes can be modulated based on the culturing conditions, allowing Vytrus to fine- tune their composition and potential activities to meet specific cosmetic requirements. Furthermore, we have demonstrated the
feasibility of plant-human cross-kingdom communication via exosomes. As natural biological communicators, these exosomes can transfer complex biological information across species barriers, thereby enhancing the efficacy of cosmetic formulations. In conclusion, as ongoing research and
development continue to advance in this field, the potential applications of plant exosomes in cosmetics appear limitless. This heralds a new era of advanced, eco-friendly beauty products, setting a new benchmark for innovation and sustainability in the cosmetics industry.
Figure 6: Regenerative properties of the active at eight days, compared to the EGF effect (pictures of 3 different biopsies are shown for both EGF and Turmeria Zen). Data from the Norwitch Skin Platform, University of East Anglia
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References 1. Alzahrani FA, Khan MI, Kameli N, Alsahafi E, Riza YM. Plant-Derived Extracellular Vesicles and Their Exciting Potential as the
November 2024 PERSONAL CARE
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