84 MARINE INGREDIENTS VOLUNTEER #6 (MAN) 1.5% MARINE INGREDIENT ** p<0.01; ***p<0.001
D0 0 5 Height (µm) -300 -200 -100 0 100 200 10 15 20 Width (mm) 25 30 35 40 0 5 10 15 20 Width (mm) under-eye bags volume on average -4.1%***
Figure 4: Evaluation of under-eye bags volume by Primos 3D Glowy skin refers to a healthy, radiant
complexion that appears naturally luminous, fresh, and hydrated. Glowy skin is often associated with the ‘glass skin’ trend from South Korea (K-beauty), known for its smooth, reflective surface that creates a mirror-like finish. A biological strategy to achieve a radiant skin is microcirculation. It ensures the nutrition and oxygenation
of the epidermis, dermis, and hypodermis. It eliminates waste products from their metabolism and helps maintain the homeostasis of the internal environment. The condition of the cutaneous vessels partly determines skin colour. Activating the microcirculation enhances
blood flow delivering oxygen and nutrients to cells, supporting cellular health and energy production. Good microcirculation significantly increases the skin’s barrier function and its quality, particularly its radiance.9
to stimulate microcirculation and activates lymphatic drainage. Moreover, to keep maintaining a luminous
complexion, it is important to support skin detoxification, as the skin is the largest detox organ in the human body.
Clinical efficacy on skin radiance A clinical test, evaluating the efficacy of a cream with 1.5% of the active ingredient derived from Codium fragile has been conducted on 33 volunteers (mixed panel). For 28 days, twice daily, they applied the cream on hemi-face. After evaluation of the overall skin
radiance by direct grading, the 1.5% active ingredient demonstrated an overall radiant benefit on complexion by lighting up the skin. This evaluation has been determined by a dermatologist after 14 and 28 days. It revealed a fresh and luminous complexion. The more the days of application through
this clinical test, the more the impact of this marine ingredient, on skin radiance.
Clinical efficacy on skin elasticity In the purpose of another clinical test, 33 volunteers (mixed panel) average age 51, with wrinkles around the eyes, applied for 28 days, twice daily, on hemi-face 1.5% of the active ingredient in a cream. It has been observed, after a cutometer
PERSONAL CARE March 2025
measurement, that the net elasticity (R5) of the skin increased. Thus, the skin is more resilient after a deformation, it reverts quickly to its physiological state. The active ingredient enhances the skin firmness for an anti-ageing benefit from 14 days. Regarding biological elasticity, this in vivo test showed a significant increase of the biological elasticity (R7) of the skin, the latter representing physiological range of the skin in non-stressed condition. The global skin elastic properties are strengthened for a skin full of vitality.
It is beneficial
Formulation tips This marine ingredient is a concentrated form of sulfated arabinogalactans obtained from aqueous extraction of the intracellular polysaccharides of the organic seaweed Codium fragile. This green organic certified alga from Portuguese coasts, is reasonably cultivated and harvested by hand, while respecting the marine environment. This is a water-soluble active ingredient,
with more than 95% natural origin content (ISO 16128), Vegan, COSMOS and NATRUE approved. It is easy to formulate with a wide pH stability range. Additionally, it has a perfect stability
to temperature, as it can withstand high temperature (70°C) for a short time (up to six hours). The marine ingredient provides detoxifying and illuminating benefits to the skin and eye contour, revealing the eye beauty, and restoring skin youth and radiance.
Conclusion In conclusion, Codium fragile extract, rich in sulfated arabinogalactans, derived from green algae represents a promising breakthrough in combating water under-eye bags/eye contour area while enhancing skin radiance and elasticity. Its unique composition of sulfated arabinogalactans offers potent bioactive properties that address the specific challenges of the delicate eye contour area. Through its anti-inflammatory properties,
the extract mitigates IL-6 and IL-8 expression, crucial in reducing vascular permeability and fluid retention. Additionally, its draining capabilities
enhance microcirculation, improving lymphatic and blood flow to effectively reduce under- eye bags. Clinical studies have validated its
25 30 35
D14 40 0 5 10 15 20 Width (mm) under-eye bags volume on average -5.9%**
efficacy, demonstrating significant reductions in under-eye bag volume and visible improvements in skin texture and appearance, magnifying the complexion. As a sustainable and effective marine-
derived solution, Codium fragile extract exemplifies the transformative potential of blue biotechnology in skin care, offering innovative and scientifically validated solutions for enhancing skin beauty and health.
References 1. Senseofwellness-mag. Marine Cosmetics Diving deep into the secrets of visionary beauty Magazine #7, summer 2018
2. Jesumani V, Du H, Aslam M, Pei P, Huang N. Potential Use of Seaweed Bioactive Compounds in Skincare—A Review. Mar. Drugs. 2019; 17(12), 688
3. Jayawardhana HHACK, Jayawardena TU, Sanjeewa KKA, Liyanage NM, Nagahawatta DP, Lee H-G, Kim J-I, Jeon Y-J. Marine Algal Polyphenols as Skin Protective Agents: Current Status and Future Prospectives. Mar. Drugs. 2023; 21, 285
4. Khora SS et al. Oyster Thief (Codium fragile): A Vital Marine Alga. International Journal of PharmTech Research. 2016; 9(5), pp 315-328
5. Kim J, Choi JH, Oh T, Ahn B, Unno T. Codium fragile Ameliorates High-Fat Diet-Induced Metabolism by Modulating the Gut Microbiota in Mice. Nutrients. 2020, 12(6), 1848
6. Petreaca ML, Yao M, Liu Y, DeFea K, Martins-Green M. Transactivation of Vascular Endothelial Growth Factor Receptor-2 by Interleukin-8 (IL-8/CXCL8) Is Required for IL-8/CXCL8-induced Endothelial Permeability. Mol Biol Cell. 2007; vol. 18, 5014 –5023,
7. Kang S, Kishimoto T. Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms. Exp Mol Med. 2021; Jul;53(7):1116-1123
8. Guthrie GP Jr. Angiotensin Receptors: Physiology and Pharmacology. Clin Cardiol. 1995; Vol. 18 (Suppl. 111), 111-29-111-34
9. Shiseido. Lifeblood Research. 23 July 2021.
https://www.industries-cosmetiques.fr/ lifeblood-research-la-correlation-entre- microcirculation-et-vieillissement-cutane- est-prouvee/
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