SKIN CARE -86%# 40 20
77 Control (Untreated) ■ 0.00025% Enriched Oat Beta Glucan ■
30
15
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10
Treated with Enriched Oat Beta-Glucan resulted in more cells with longer telomeres
5 10 0 0 (Untreated) Control
0.00025% Enriched Oat Beta-Glucan
Figure 2: Telomere shortening rate (in base pairs (bps)) after 42 days with enriched OBG treatment. T-test, significant: *=p<0.05 (95%)
and diminished radiance, underscoring the significant role of telomeres in maintaining skin health.
Enriched beta-glucan active as a waterless, multifunctional and clinically proven ingredient Oat Cosmetics has developed an enriched oat beta-glucan (OBG) active (Avena sativa (Oat) Bran Extract). This powder active is obtained from oat bran subjected to enzymatic treatment and wet milling, followed by centrifugation and ultrafiltration (the manufacturing process is optimised to preserve the original and natural structure of
DAY 0 DAY 7 Telomere Lenght (bps)
Figure 3: Telomere length distribution after 42 days with enriched OBG treatment
oat molecules). The ingredient contains a high
concentration of oat beta-glucan enriched with starches, lipids and tryptophan. In this article, the efficacy of enriched OBG in enhancing skin resilience and promoting healthy ageing (skin longevity) is presented. The first section demonstrates OBG’s ability to protect the skin at the cellular level and the second section validates the proven visual rejuvenation of the skin with enriched OBG, resulting in a smooth and radiant glow.
Preventing telomere shortening with enriched oat beta-glucan
DAY 28
Telomeres play a vital role in cellular processes. Reducing telomere shortening is critical to delay ageing and has been recognised as one of the best biomarkers of ageing.3 An in vitro study was conducted to assess
the protective effect of enriched OBG on telomeres health using primary adult human fibroblast cells. Cells were cultured with 0.00025% enriched OBG diluted in water and telomere health indicators were measured as follows. Cell proliferation: cell growth was
monitored with a cell counter (Countess™) and population doubling was calculated at each passage. Telomerase activity: telomerase activity
was measured using a quantitative telomeric repeat amplification protocol after 3 days of treatment. Telomere length: telomere length was
evaluated after 42 days of treatment using high-throughput Telomere Analysis Technology® (TAT®). Fluorescent peptide nucleic acid probes were used to measure telomere length, with results quantified with Life Length’s proprietary program. Telomerase is an enzyme that adds
repeated DNA sequences (telomeric repeats) to the ends of chromosomes. By maintaining telomere length, telomerase extends the replicative lifespan of cells. After three days, 0.00025% of enriched OBG significantly increased telomerase activity by 112% (p<0.05), compared to the control. This suggests enriched OBG enhances telomerase activity and helps to preserve telomere length, promoting cellular viability. The telomere length measurements
Increase of corneocyte thickness
Figure 4: Desquamation reduction over 28 days with enriched OBG treatment
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were normalised based on the population doubling values (cell replication). The telomere shortening rates were calculated by measuring the median telomere length change (initial- final) per population doubling.
March 2025 PERSONAL CARE
Treated with Enriched Oat Beta-Glucan resulted in less cells with shorter telomeres
2000 4000 6000 8000 10000 12000 14000 16000 18000 20000
1% ENRICHED OAT BETA-GLUCAN
PLACEBO Shortening Rate (bps)
Percentage of Cells (%)
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