EXOSOMES Through its research, Exolitus has
identified these two prominent candidates, each exhibiting distinct properties tailored to addressing various skin concerns: Melissa officinalis exosomes (INCI: Melissa Officinalis Flower/Leaf/Stem Vesicles) and Raspberry exosomes (INCI: Rubus Idaeus (Raspberry) Juice Vesicles).
Melissa officinalis: From historical remedy to modern rejuvenation Melissa officinalis, or lemon balm, has a storied legacy as a medicinal plant. Revered since medieval times, it was cultivated by European monks for its wound-healing and skin- restorative properties. Esteemed by nobility, lemon balm found
its place in rejuvenating elixirs. It was found that Melissa exosomes encapsulate potent bioactive molecules, including rosmarinic and caffeic acids, recognized for their antioxidant and anti-inflammatory effects. By preserving mitochondrial function and mitigating inflammatory cascades, Melissa officinalis exosomes rejuvenate and fortify the skin.
In vitro efficacy of Exolitus Melissa exosomes Melissa exosomes downregulate inflammatory mediators such as interleukins and interferons in fibroblasts and keratinocytes under conditions mimicking inflammation. This suggests Melissa exosomes could mitigate chronic inflammation and improve skin resilience associated with
FIBROBLASTS 0H
48H
KERATINOCYTES 0H
48H
57
Figure 3: Results from an in vitro study showing the impact of milk-derived exosomes on skin cell migration 2 days after application. The graph illustrates a 20% improvement in keratinocyte and fibroblast mobility, underscoring their potential for enhancing micro-wound healing and skin regeneration
inflammatory skin disorders. Melissa exosomes exert their effects through
the mitochondria of fibroblasts, which are crucial in mediating inflammation in the skin. Dysfunctional mitochondria, often seen in ageing and cellular senescence, contribute to oxidative stress and reduced cellular repair.18 By restoring mitochondrial efficiency, Melissa
exosomes not only reduce inflammatory responses but work as anti-ageing ingredients by improving oxidative phosphorylation and supporting skin’s energy production.
Raspberry exosomes: advanced antioxidant defence Raspberry exosomes exemplify the next frontier
www.personalcaremagazine.com
March 2025 PERSONAL CARE
EXOSOMES
CONTROL
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