62 UPCYCLED INGREDIENTS
of R2 and a decrease of R6 suggest the improvement of skin elasticity. The statistical analysis was performed by dividing the subjects into two groups: older and younger groups (Figure 9). In the younger group (age; 38.6±4.4), the values of R2 and R6 did not show significant changes by the application of either toners. In the older group (age; 49.2±2.9), the toner
containing glucosyl naringin active significantly increased the value of R2 and significantly decreased the value of R6, while the placebo toner did not have significant changes in either value. Also, after eight weeks of application,
there was a significant difference in the R2 value between the toners with and without glucosyl naringin active. These results indicate the improvement of skin elasticity in the older group. It has been reported that skin elasticity
decreases age-dependently, thus it can be assumed that glucosyl naringin active improves the skin elasticity loss caused by ageing.8
Therefore, it is expected to be more
effective for elderly people facing the age- related changes: loss of skin elasticity leading to wrinkles and sagging.
Conclusion Glucosyl Naringin is an upcycled ingredient derived from inedible citrus fruit which is readily biodegradable and produced by sustainable manufacturing. In vitro studies confirmed the enhancement of elastin production and fibre formation, indicating the effects on both the quantity and the quality of elastin. Also, pre-clinical study showed that
continuous treatment improved skin elasticity in the older group of subjects, suggesting that glucosyl naringin active can improve skin
Uv Ur Ua
R2= Ua/Uf Recovery ratio of the skin length
R6= Uv/Ue Ratio of viscosity and elasticity part when elongated
Ue Uf
Release Skin suction Figure 8: Skin elasticity parameter using a skin elasticity meter
elasticity loss caused by chronological ageing. Moreover, there is a report showing that it also has effects on collagen fibres, increasing type 1 collagen expression and enhancing the gene expression of cell adhesion related factors.9 This provides an insight indicating that
glucosyl naringin active approaches both the tensile strength provided by collagen fibres and the elasticity provided by elastin fibres of skin dermis, which offers significant value for ageing care active. Today, as life expectancy increases, more
and more consumers are seeking healthy lifestyles and well ageing. Glucosyl naringin active satisfies those seeking self-esteem, a good feeling about themselves to age naturally, and sustainability for the planet. It revives healthy skin for an affluent and
Younger group
0.7 0.6 0.5 0.4 0.3
Week 0 1.1 0.9 0.7 0.5 Week 0 Week 4 Week 8 Week 4 Younger group 1.1 0.9 0.7 * 0.5 Week 0 Week 4 Week 8
Figure 9: Change of the skin elasticity after treatment with or without glucosyl naringin active N=8 (younger group) or 9 (older group), Mean ± SD, *p<0.05, **p<0.01 vs. Week 0 (Dunnett’s test), #p<0.05 (paired t-test)
PERSONAL CARE September 2023 Week 8
0.7 0.6 0.5 0.4 0.3
Week 0 Week 4 Older group
■ Placebo ■5.0mg/g glucosyl naringin active Older group
** #
progressive generation, enabling them to engage in their proactive and comfortable lives which leads to holistic well ageing.
References 1. Imarc. Size of the anti-aging market worldwide from 2021 to 2027 (in billion U.S. dollars). 28 March 2022. Statista. https://
www.statista.com/statistics/509679/value- of-the-global-anti-aging-market/
2. Sharma A, Bhardwaj P, Arya SK. Naringin: A potential natural product in the field of biomedical applications. Carbohydrate Polymer Technologies and Applications. 2021;2(25):100068
3. Fujimura T, Haketa K, Hotta M, Kitahara T. Loss of skin elasticity precedes to rapid increase of wrinkle levels. Journal of Dermatological Science. 2007;47(3):233-239
4. Baumann L, Bernstein EF, Weiss AS, Bates D, Humphrey S, Silberberg M et al. Clinical Relevance of Elastin in the Structure and Function of Skin. Aesthetic Surgery Journal. 2021;3(3):ojab019
5. Ozsvar J, Yang C, Cain SA, Baldock C, Tarakanova A, Weiss AS. Tropoelastin and Elastin Assembly. Frontiers in Bioengineering and Biotechnology. 2021;9:643110
Week 8
6. Uitto J, Li Q, Urban Z. The complexity of elastic fiber biogenesis in the skin – a perspective to the clinical heterogeneity of cutis laxa. Experimental Dermatology. 2013;22(2):88-92
7. Montagna W, Carlisle K. Structural Changes in Aging Human Skin. The Journal of Investigative Dermatology. 1979;73(1):47-53
8. Lynch B, Pageon H, Blay HL, Brizion S, Bastien P, Bornschlögl T et al. A mechanistic view on the aging human skin through ex vivo layer-by-layer analysis of mechanics and microstructure of facial and mammary dermis. Scientific Reports. 2022;12:849
9. Kawashima E, Kobayashi T, Mizutani Y. Glycosylated naringin promotes fibrillin-1 formation and collagen synthesis. Fragrance Journal. 2020;8:16-21
www.personalcaremagazine.com PC
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