44 MARINE INGREDIENTS
Sargassum bioferment Regulation of miRNAs involved in DNA repair processes
miR-96
miR-598 miR-720 miR-429
0
Reduction in miRNA level (%)* 75
25 50 100
*Corresponds to an increase in gene expression / protein production
Figure 6: Beneficial regulation of microRNAs involved in DNA repair processes and ECM synthesis
sensitive ‘biological glue in the ECM called ECM1 was also induced.24,25
LAMA2, an essential
factor for skin cell renewal typically decreased by photoageing25
, was elevated in Sargassum
bioferment-treated skin cells. Similarly, the level of TIMP3, which is usually diminished in response to UV and ageing,26
was
renewed with Sargassum bioferment. Notably, TIMP3 helps inhibit UVB-induced inflammatory cytokines.27 Lastly, the Sargassum bioferment
strongly repressed expression of the matrix metalloproteinases, MMP1 and MMP3, involved in ECM degradation. By reducing these matrix- degrading enzymes, the Sargassum bioferment helps to support a more robust ECM in the skin. Together, these results show that the
Sargassum bioferment beneficially modulates the expression of essential ECM genes to maintain a youthful appearance of UV-exposed skin.
Conclusion DermalRx FSE supports the skin for applications in pre- and post-sun care products and as part of protective anti-pollution and anti- ageing regimens, exemplifying what is possible when marine species and biotechnology are combined to manufacture potent, biofunctional materials.
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5. Mouret S, Baudouin C, Charveron M, Favier PERSONAL CARE September 2023
nucleotide excision repair base excision repair double strand break repair
ECM protection
nucleotide excision repair double strand break repair
cell cycle delay for DNA repair apoptosis for severe damage
ECM synthesis barrier integrity
Sargassum bioferment Regulation of gene expression
type V collagen
COL1A1 COL5A1
type VII collagen
matrix associated protein 1
COL7A1 ECM1
LAMA2 laminin MMP inhibitor 3
SPARCosteonectin TIMP3
metalloproteinase 1
MMP1 MMP3
matrix metalloproteinase 3 0% 100% 200% 400% 600% 800% Gene Expression
Figure 7: The Sargassum bioferment promotes beneficial modulation of genes involved in ECM maintenance
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www.personalcaremagazine.com matrix
*** p<0.001 ** p<0.01 * p<0.05
type I collagen
***
***
*** *** *** ** *** ** *
decreased expression of genes involved in ECM degradation
increased expression of genes supporting ECM biosynthesis
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