ANTI-AGEING
nasolabial fold and surrounding area were measured using ANTERA 3D (Miravex), which identifies topographic information. As shown in Figure 6A, degree of the nasolabial fold was represented by the colour in the topographic image, it was confirmed that the overall size was significantly reduced in the active group compared with the placebo group. In addition, width and depth of the wrinkles
were also significantly reduced (data not shown). The degree of skin surface roughness was significantly reduced in the active group, confirming a useful change in appearance (Figure 6B). Marks on the inner forearm were measured
using Antera 3D (Miravex), as above. This study was to assess the preventive effect of leaving skin marks. The forearm was tied with a rubber band, and the indentation volume of remaining mark was calculated after applying a linear load for one minute. As shown in Figure 7, comparing the images
before and four weeks after applying the active lotion, the extent of marks as indicated by green line was significantly reduced. This means that the volume of the remaining mark with rubber band has decreased. The graph showed the amount of colour in the image, and the remaining marks was significantly reduced after four weeks in the active group. These results suggest that continuous
use of DCE has the ability to improve age- related indicators to youthful skin levels. This extract could also be expected to improve the resilience against mechanical and physical stresses such as mask marks, sleep marks, and underwear marks.
Conclusion Dianthus caryophyllus flower extract is an anti- ageing ingredient that prevents the reduction of
Female in her 40s A Young skin DCE Aged skin Placebo 0.8 0 5 Elapsed time (seconds)
Figure 5: Effect on improving skin texture. Skin deformation due to ageing and the analysis of the resilience on the lid-cheek junction were shown. Each value is presented as the mean ± SEM. *; p < 0.05 (paired t-test). †; p < 0.05 (Student’s t-test)
skin softness and resilience, which are closely related to skin ageing signs such as wrinkles, sagging, and remaining marks, through the production of type III collagen.
11. Maeda K. Cosmetics 2018; 5: 14 12. Lochner K et al. Biogerontology 2007; 8: 269–282
PC
References 1. Muramatsu S et al. J Dermatol Sci. 2005; 37: 151–158
2. Yagi M, Yonei Y. Glycative stress research 2018; 5: 50–54
3. Varani J et al. Am J Pathol. 2006; 168: 1861–1868
4. Lee DH et al. J Dermatol Sci. 2016; 83: 174–181 5. Ricard-Blum S. Cold Spring Harb Perspect Biol. 2011; 3: a004978
6. Smith LT. Am J Anat. 1986; 175: 507–521 7. Kisling A et al. Life Sci. 2019; 228: 30–34 8. Weber L. J Invest Dermatol. 1984; 82: 156–160 9. Vitellaro-Zuccarello Let al. Cell tissue Res. 1992; 268: 505–511
10. Sriram G et al. Eur J Cell Biol. 2015; 94: 483–512 Female in her 40s
13. Brincat M et al. Br J Obstet Gynaecol. 1985; 92: 256–259
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al.Maturitas 1999; 33: 239–247 15. Youn CS et al. Acta Derm Venereol. 2003; 83: 419–424
16. Cheng Wet al. Afr j biotechnol. 2011; 10: 2524–2529
17. Hasty KA et al. J Biol Chem. 1987; 262: 10048–10052
18. Amar S et al. Biochim Biophys Acta Mol Cell Res. 2017; 1864: 1940–1951
19. Prox J et
al.Matrix Biol. 2015; 44–46: 7–13 20. Kronenberg D et al. J Invest Dermatol. 2010; 130: 2727–2735
21. Broder C et al. Proc Natl Acad Sci U S A. 2013; 110: 14219–14224
22. Liu X et al. Proc Natl Acad Sci U S A. 1997; 94: 1852–1856
10 0.9 1.0 1.1 Resiliency at 4 weeks (fold change from baseline) 1.2 * + B
75
A DCE Placebo 0.8 B DCE Placebo 0.8 0.9 1.0
Surface roughness at 4 weeks (fold change from baseline)
Figure 6: Effect on improving the appearance of the skin. Evaluation of images and analysis of wrinkles (A) and surface roughness (B) on the nasolabial fold and its surrounding area were shown. Each value is presented as the mean ± SEM. **; p < 0.01 (paired t-test). †; p < 0.05, ††; p < 0.01 (Student’s t-test)
www.personalcaremagazine.com 1.1 0.9 1.0 Wrinkle size at 4 weeks (fold change from baseline) Placebo + 0.4 0.6 0.8 1.0
Volume of hollow at 4 weeks (fold change from baseline)
Figure 7: Preventive effect on remaining skin marks. Evaluation of images and analysis of the remaining skin marks on the inner forearm were shown. Each value is presented as the mean ± SEM. **; p < 0.01 (paired t-test)
November 2022 PERSONAL CARE 1.2 1.1 ** ++
Dianthus carophyllus flower extract (%)
**
baseline
4 weeks
Skin deformation
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