44 ANTI-POLLUTION
Hair treatment with natural active ingredient diminishes split ends, improves fibre alignment, frizz, and volume control The ability of natural active ingredient to improve frizz and volume control were evaluated globally on the hair of volunteers by a hair expert at initial time and after 14 days of product application using a 0-4 scale. The same expert grade the same subjects throughout the study.
The hair expert was not allowed to reference
previous scores at post-baseline assessments. As shown in Figure 6, treatment with the natural active ingredient reduces hair frizz significantly. For hair volume control, volunteers with
curly and coiled hair (hair types from 3A to 4C) were evaluated as described before at initial time and after 14 days of product application. Figure 7 shows the improvement in hair volume control by -19.9% after natural active ingredient treatment.
Discussion It is well reported that oxidative stress initiates complex biological processes that lead to the oxidation of major macromolecules - such as lipids, proteins and deoxyribonucleic acids - to impact the quality of the skin and hair.5-9
Here,
we have demonstrated that exposome stress can induce severe damage of human skin, scalp, and hair. In the skin, we have shown that exposome-
induced stress damage may cause dysfunction to the skin barrier, the body’s first line of defence to external damage. This may lead to an increase of transepidermal water loss, which may make the skin more susceptible and more vulnerable to subsequent exposures to external aggressors. In the hair, we have shown that exposome
damage can also lead to reductions in hair vitality. Exposome damage may cause cuticle damage, which allows moisture to pass through and swell the hair strands, leading to hair frizz.
Conclusion Xpozuki biotech ingredient is a new natural active ingredient that acts as an all-in-one product, being able to protect the skin, scalp, and hair against the exposome, including the combined effect of UV radiation, air pollution, greenhouse stress, and pollen.
0 -5
-10 -15
-20 -25 -30
Placebo I.S. -19.9% 2% natural active ingredient
Figure 7: A. Variation in hair volume after 14 days of treatment with natural active ingredient at 2%. Data shown as Mean increase including statistical significance: l.s <0.01 vs. initial time. Wilcoxon test was used after checking the normality distributions by a Shapiro-Wilk test. B. Hair photographs of a volunteer with Afro-textured hair (type 3C), before and after 14 days of treatment and overlapping images showing frizz control.
PERSONAL CARE November 2022
www.personalcaremagazine.com 0
-2 -4 -6 -8
-10 -12 -14 -16 -18
Placebo 0 DAYS 14 DAYS
2% natural active ingredient - **
13.6%
Figure 6: A. Variation in hair frizz after 14 days of treatment (**p<0.01 vs. initial time) vs. placebo. Wilcoxon test was used after checking the normality distributions by a Shapiro-Wilk test. B. Hair photographs of a volunteer with Afro-textured hair (type 4B), before and after 14 days of treatment showing frizz control
In vitro, the active ingredient can protect
skin and scalp cell viability and repairing the damage after exposome stress damage. It also protects the hair fibre from protein carbonylation and lipid peroxidation. In vivo, it resulted to an improved skin
tone evenness and skin texture homogeneity, decreasing exposome stress damage to the skin. Furthermore, application to the hair as a leave on serum shows to present a multifunctional effect, improving frizz and volume control on multiethnic hair types. This biotech ingredient can be used in skin,
scalp, and hair care formulations to support all consumers to feel more protected against environmental aggressors, empowering them to explore, discover, and enjoy the great outdoors once again.
Acknowledgements The authors would like to thank all research technicians and scientists from Lipotec´s R&D department for their contributions during the development of this project.
Physiol. 2007;20(6):297-304. doi: 10.1159/000108101. Epub 2007 Sep 11. PMID: 17851273
3. Pointner L, Bethanis A, Thaler M, Traidl- Hoffmann C, Gilles S, Ferreira F, Aglas L. Initiating pollen sensitization - complex source, complex mechanisms. Clin. Transl. Allergy. 2020 Aug 31;10:36. doi: 10.1186/ s13601-020-00341-y. PMID: 32884636; PMCID: PMC7461309
4. Grover SR. Global warming and its impact on skin disorders. Indian J. Dermatol. Venereol. Leprol. 2009;75:337-339
5. Denisow-Pietrzyk M. Human Skin Reflects Air Pollution – a Review of the Mechanisms and Clinical Manifestations of Environment- Derived Skin Pathologies. Polish Journal of Environmental Studies. 2021;30(4):3433- 3444. doi:10.15244/pjoes/130525
PC
References 1. Krutmann J, Bouloc A, Sore G, Bernard BA, Passeron T. The skin aging exposome. J. Dermatol. Sci. 2017 Mar;85(3):152-161. doi: 10.1016/j.jdermsci.2016.09.015. Epub 2016 Sep 28. PMID: 27720464
2. Jacobi U, Engel K, Patzelt A, Worm M, Sterry W, Lademann J. Penetration of pollen proteins into the skin. Skin Pharmacol.
0 DAYS
6. Roberts W. Air pollution and skin disorders. International Journal of Women’s Dermatology. Volume 7, Issue 1, 2021, Pages 91-97. ISSN 2352-6475. https://doi. org/10.1016/j.ijwd.2020.11.001
7. Halliwell B, Cross CE. Oxygenderived species: Their relation to human disease and environmental stress. Environ Health Perspect. 1994;102 Suppl 10:512
8. Kampa M, Castanas E. Human health effects of air pollution. Environ. Pollut. 2008; 151:362 7
9. Kohen R, Gati I. Skin low molecular weight antioxidants and their role in aging and in oxidative stress. Toxicology. 2000; 148:149 57
14 DAYS 14 DAYS vs 0 DAYS
Variation in hair volume (%)
Variation in hair frizz (%)
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