90 SKIN CARE
Formulations with DavosLife E3 exhibited a radical skin factor (RSF) of 4.15. The RSF measures a substance’s ability to reduce free radicals generated in the skin upon UV exposure. An RSF of 4.15 suggests that tocotrienols reduce free radical production in the skin resulting from exposure to the sun’s harmful UVA and UVB rays by 76%.4 Our research showed that topical application of DavosLife E3 after UV exposure can reduce the severity of redness to a level comparable to an over-the- counter anti-inflammatory gel.4
Tocotrienols enhance wound healing Fibroblasts are critical in supporting normal wound healing. They are responsible for breaking down the fibrin clot and replacing it with extra cellular matrix (ECM) components such as collagen to support the other cells associated with effective wound healing. Tocotrienols trigger the migration of fibroblasts to the wound area suggesting Tocotrienols’ potential role in skin repair and wound healing. The skin repair properties of DavosLife E3 was investigated using MatTek’s EpiDerm FT in vitro skin model. The in vitro skin was treated topically with 1% α-tocopherol, DavosLife E3 or control. Our research indicates that after 6 days of treatment, DavosLife E3 stimulate epidermal migration and skin repair more than twice as fast as α-tocopherol.5
Tocotrienols maintain cellular health Results from pre-clinical studies showed that tocotrienols have the ability to prevent cellular ageing by reversing the effects of oxidative stress in human diploid fibroblasts (HDF). In addition, tocotrienols increased the length of DNA structures called telomeres. Telomeres grow progressively shorter each time a cell divides. In most cells, the length of the telomere is closely associated with cellular ageing: the shorter the telomere, the older the cell.4
A
randomised, double-blind, placebo- controlled study with 64 human subjects aged 37-78 years old showed a significant reduction of DNA damage in their blood
Figure 1: After 6 days of treatment, DavosLife E3 stimulates epidermal migration and skin repair more than twice as fast as α-tocopherol.
Results from these studies show that tocotrienols have the potential for maintaining cellular health.
samples after 3 months of 160 mg daily dose of tocotrienols. The positive effects continued until the end of the trial for 6 months.6
Conclusion DavosLife E3 (formerly known as Naturale3
)
DVL range of products contains a complete spectrum of all tocotrienol isomers (α-, β-, γ- and δ-) and α-tocopherol, as occurs naturally in an optimal ratio for overall health benefits, not limiting to promoting skin health and protection. It is an amber coloured liquid miscible with oil, partially miscible with ethanol and immiscible with water. DavosLife E3 DVL is highly stable under a wide array of pH conditions and temperature range, which makes it ideal for formulation in cosmetics and personal care products. With our proprietary technology,
DavosLife E3 DVL 95 contains the highest concentration of mixed tocotrienols and α-tocopherol available in the market. It is suitable for skin care applications due to its less intense colour (light yellow) and viscosity. Safety assessment conducted by the Cosmetic Ingredient Review (CIR) Expert Panel concluded that tocotrienols are safe as used in cosmetics. DavosLife E3 DVL range of tocotrienols products have been granted attestation by Ecocert Greenlife and assessed as compliant with Cosmos standard.
Davos Life Science will showcase DavosLife E3 range of Tocotrienol-Rich Fraction products at KLK OLEO’s booth No J90 at in-cosmetics Asia, Bangkok, Thailand on 31 October to 2 November 2017.
PC
Reference: 1 Saito Y, Yoshida, Y, Nishio K, Hayakawa M, Niki E. Characterization of cellular uptake and distribution of vitamin E. Ann. N. Y. Acad. Sci.,2004; 1031, 368–75.
2 Davos Life: Data on File. 3 Yap WN, Zaiden N, Xu CH, et al. Gamma- and delta- tocotrienols inhibit skin melanin synthesis by suppressing constitutive and UV-induced tyrosinase activation. Pigment Cell Melanoma Res., 2010;23: 688–692.
4 Makpol S, Abidin AZ, Sairin K, et al. Gamma- Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals. Oxid Med Cell Longev 2010; 3(1): 35-43.
5 Serbinova E, Kagan V, Han D, Packer L. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free RadicBiol Med. 1991; 10(5): 263-75.
6 Chin SF, Hamid NA, Latiff AA, et al. Reduction of DNA damage in older healthy adults by Tri E Tocotrienol supplementation. Nutrition 2008; 24(1): 1–10.
PERSONAL CARE ASIA PACIFIC November 2017
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