SKIN CARE 41
Effect of fullerene on conspicuous facial pores
n Hisae Aoshima PhD – Vitamin C60 BioResearch Corporation, Japan
‘Conspicuous facial pores’ tend to be thought of as a problem specific to young individuals. It is certainly more common in teenagers and those in their 20s but older individuals may also have facial pores that are problematic. In fact, more than 70% of the middle-aged individuals and those in their 30s to those in their 60s responded as “concerned about facial pores”. Therefore, in recent years, this problem has drawn much attention from the cosmetics industry so as to develop measures against it. Sebum is one of the causes of conspicuous facial pores. A positive correlation has been reported between the amount of sebum and the size of pores, and conspicuous facial pores in young people are closely associated with sebum and keratin plugs.
It is said that the amount of sebum has little to do with conspicuous facial pores in middle-aged individuals and seniors as secretion of sebum decreases with age. It has been reported that the size of facial pores has a negative correlation with skin elasticity and softness of the skin, and the causes of conspicuous facial pores in middle-aged individuals and seniors are associated with decreased resilience of skin
Abstract
The reduction of conspicuous facial pores is of great interest in cosmeceuticals. We evaluated the effect of fullerene application on conspicuous facial pores by using the VISIA system and by microscopic observation in a clinical trial. The fullerene lotion remarkably reduced the conspicuous facial pores over 8 weeks. To investigate the mechanism by which fullerene reduces facial pores, we examined its effects in suppressing ultraviolet B (UVB)-induced prostaglandin E2 (PGE2
) production using
reconstructed human epidermis (RhE). UVB irradiation of RhE increased PGE2 production, and the application of fullerene significantly suppressed the UVB-induced PGE2
in the epidermis. In addition, fullerene is thought to contribute to the prevention of lipid peroxidation through its radical scavenging properties.
due to ageing. Various factors such as sebum, keratin plugs, and changes in the tissue due to ageing are involved in conspicuous facial pore formation depending on age group. We have received numerous reports that: “the continuous use of fullerene- containing cosmetics made facial pores less noticeable,” from dermatologists and consumers who used fullerene-containing cosmetics manufactured and sold by Vitamin C60 BioResearch Corporation (VC60 Corporation). It has been reported
that a vitamin C derivative, which has active-oxygen–scavenging effects similar to those of fullerene, inhibited the activation of melanocytes and reduced conspicuous facial pores.1
We believe fullerenes, which
we will discuss later, may be effective in reducing conspicuous facial pores as they also have excellent active oxygen– scavenging effects. Pigmentation caused by activation of melanocytes in the pores due to the skin being exposed to ultraviolet (UV) light, in addition to excessive secretion and oxidation of sebum, is known to be one of
production. These results suggest that 8 weeks of treatment with fullerene can reduce conspicuous facial pores, possibly through the suppression of PGE2 production
Figure 1: Causes of noticeable pores. November 2017 PERSONAL CARE ASIA PACIFIC
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