MALE GROOMING 25
Regain hair density naturally with new active ingredient
n Mélanie Coirier, Emilie Lasjaunias, Brigitte Closs – Silab, France
A dense head of hair is the result of an equilibrium between loss and regrowth. Loss is a natural phenomenon: a healthy person loses between 50 and 125 hairs every day. Accelerated hair loss whose scientific name is alopecia, is seen as a sign of premature ageing and therefore can have a considerable effect on the quality of life of individuals affected.1 Androgenetic alopecia is a common
disorder involving up to 30% of men younger than 30, and more than 50% of men older than 50.2
appearance of thinner, shorter and unpigmented hair, forming a down. Genetic and hormonal factors are the two principal culprits, causing hypersensitivity to a hormone: dihydrotestosterone (DHT). This hormone is responsible for all biological modifications occurring in this disorder. However, certain environmental parameters may contribute to the appearance of androgenetic alopecia. These include the repeated use of aggressive hair treatment products (dyes and other chemical treatments), smoking or exposure to UV.3,4,5 At the present time, two chemical molecules are commercialised to treat androgenetic alopecia. Unfortunately, they are effective in less than half the cases and their side effects are considerable (oily hair, appearance of dandruff, skin irritations, libido issues). This is why there is a genuine need to propose a new approach to favour hair growth at the same time as preventing the above-mentioned side.6,7,8 In this context, Silab develops Hairgenyl®
,
an anti-hair loss active ingredient that is eco- designed using the company’s extensive expertise in biotechnologies. It is rich in peptides obtained from the yeast Pichia minuta, isolated from the flowers of azalea, Rhododendron indicum (Fig 1). This patented product is a preservative-free powder, resulting from a non-denaturing industrial process. The efficacy on cells and tissues was
proven on 2D and 3D models submitted to a DHT simulation in order to mimic androgenetic alopecia. The results revealed that the azalea-isolated yeast active targets the functions of three major regulation
November 2017 It is characterised by the progressive Abstract
Androgenetic alopecia results from a deregulation of the hair growth cycle, mainly affecting men and characterised by thinner, shorter and unpigmented hair, forming a down.
Silab tackles this disorder with Hairgenyl® , a natural anti-hair loss active ingredient
from biotechnological origin. The efficacy studies conducted on the product were aiming at determining in vivo on a panel of male volunteers its hair growth and anti-hair loss action. The results were supported by a self-evaluation questionnaire filled out by volunteers to confirm the performance of the ingredient. With its biological activity at the heart of the hair follicle biology, this natural active is
recommended for thicker and more resistant hair as well as a more densely covered scalp, with the objective of limiting baldness.
factors in hair regeneration which are deficient and/or defective in the course of androgenetic alopecia (data not shown in this publication): l Mitochondrial dynamics Hair growth is an energy- consuming process. This energy is provided by the mitochondria, cells’ “power plants”. They are dynamic organelles whose morphological configuration determines energy production that is an emerging concept in hair biology. l Signalling molecules
Signalling molecules enable cells to communicate among themselves. In hair
Figure 1: Pichia minuta yeast, isolated from the flowers of azalea, Rhododendron indicum.
PERSONAL CARE ASIA PACIFIC
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