SKIN PROTECTION 39 105 100 95 90 85 80 0W 8W


manufacturers willing to develop an anti-ageing finished product based on skin care against environmental pollution, particularly tobacco smoke and PM2.5.


References 1 Urbanization and health. Bull World Health Organ, 2010; 88: 245-246.


2 Vierkotter A, Schikowski T, Ranft U, Sugiri D, Matsui M, Kramer U, Krutmann J. Airborne particle exposure and extrinsic skin aging. J Invest Dermatol. 2010; 130: 2719-2726.


3 Morita A, Torii K, Maeda A, Yamaguchi Y. Molecular basis of tobacco smoke-induced premature skin aging. J Invest Dermatol. 2009; 14: 53-55. 4 Krutmann J, Liu W, Li L, Pan X, Crawford M, Sore


0w Figure 9: Ougon decreased pigmented spots as well as melanin index on the faces of smokers significantly. G, Seite S. Pollution and skin: From


epidemiological and mechanistic studies to clinical implications. J Dermatol Sci. 2014; 76: 163-168.


PC


5 Ono Y, Iddamalgoda A, Yasuda Y, Shintani Y, Sakakibara N, Morita A. A labiatae plant extract inhibits tobacco smoke extract-induced collagenase through the suppression of aryl hydrocarbon receptor (AhR) pathway. Abstract, IFSCC 2008.


6 Morita A. Tobacco smoke causes premature skin aging. J Dermatol Sci. 2007; 48: 169-175.


7 Tanaka H, Ono Y, Nakata S, Shintani Y, Sakakibara N, Morita A. Tobacco smoke extract induces premature skin aging in mouse. J Dermatol Sci. 2007; 46: 69-71.


8 Nakamura M, Ueda Y, Hayashi M, Furuhashi T,


Morita A. Tobacco smoke-induced skin pigmentation is mediated by the aryl hydrocarbon receptor. Exp Dermatol. 2013; 22: 556-558.


9 Yu M, Qu C, Overloop L, Yarosh D, Declercq L. Characterization of biological effects induced by air pollution particulate matter from Shanghai (China) in normal human epidermal keratinocytes in culture. J Invest Dermatol. 2014; 134: S67 (Abstract).


10 Furue M, Takahara M, Nakahara T, Uchi H. Role of AhR/ARNT system in skin homeostasis. Arch Dermatol Res. 2014; 306: 769-779.


11 Iddamalgoda A, Biswas KB, Tanaka K, Takayama S. Protection against pollution- induced skin ageing by a natural cosmetic ingredient. SOFW J. 2016; 142: 8-13.


8w


n Ougon Liquid n Control


Age 20s female smoker


November 2017


PERSONAL CARE ASIA PACIFIC


Relative melanin index (%)


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