NATURALS


75


Micro-Organisms


Corneous Layer


Epidermis Living


Pro-Inflammatory Cytokines and Inflammatory Mediators (IL-1, TNF a, Growth Factors)


Inflamed Cells Figure 6: The skin chemical barrier


human epidermis (RHE) using qPCR technology for bacterial counting. Overall, the experimental conditions


demonstrated a decrease in bacterial adhesion when the reconstructed human epidermis was treated with the skincare active at concentrations of 0.5%, 1%, and 2.5%. The product consistently increased the


proportion of Staphylococcus epidermidis while reducing the presence of Staphylococcus aureus and, to a lesser extent, Corynebacterium xerosis. This indicates the potential of the skincare active to modulate the skin’s microbial environment in a way that promotes a healthier and more balanced skin microbiota, resulting in improved skin clarity and balance. By evaluating the anti-microbial effect of


the skincare active on human keratinocytes, the study aimed to determine the product’s ability


S.epidermidis ■ C.xerosis ■ S.aureus ■ C.acnes ■


120 100 80 60 40 20 0


+9% +21% +35% +51% +35% Control 0.5% 1% 2.5%


Figure 7: Evaluation of the adhesion of four bacterial strains: Staphylococcus epidermidis, Staphylococcus aureus, Corynebacterium xerosis, and Cutibacterium acnes


+57% +64% +8% +13% +28%


+7% +11%


+25%


+8% +8%


+20%


Constituent Antimicrobial Peptides (Psoriasine)


Induced Antimicrobial Peptides (β-Defensines, Rnase 7, LL-37)


www.personalcaremagazine.com


October 2023 PERSONAL CARE


Ratio


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