66 HYGIENE
safe for everyday use”, further substantiating its gentle nature on the skin. During the study, the test product
successfully navigated through the induction phase (21-day repeated insult patch test) as well as the sensitization phase, which was subsequently followed by three challenge tests. This comprehensive examination culminated in the conclusion that the coconut-derived antimicrobial active can be confidently categorized as ‘hypoallergenic’. This classification stems from its demonstrated ability to exhibit a low probability of causing allergic reactions, even among individuals with sensitive skin. These findings highlight the product’s
exceptional profile in terms of dermatological safety and hypoallergenicity. The coconut- derived antimicrobial active’s capability to undergo the series of rigorous tests without inducing adverse skin reactions or sensitization further solidifies its suitability for diverse skin types. This outcome is significant not only for its application in cosmetic and personal care products but also for instilling consumer confidence in its safety and compatibility with sensitive skin. In summary, the dermatological
hypoallergenicity study establishes the coconut-derived antimicrobial active’s credentials as a skin-friendly ingredient. Its performance in the assessment, including the low irritation potential, ‘dermatologically tested as safe for everyday use’ designation, and hypoallergenic classification, collectively highlight its gentle yet effective nature, positioning it as a reliable choice for formulations targeting consumers with sensitive skin concerns.
Enhancing the skin’s barrier and moisture Figure 1 illustrates the transepidermal water loss (TEWL) data resulting from hourly hand washing using soap samples, both with and without the inclusion of a coconut-derived antimicrobial active. The data is presented as a percentage change, wherein lower TEWL values indicate improved skin moisture retention and a stronger skin barrier function. Notably, when the soap contained 0.5%
of the coconut-derived antimicrobial active, a significant reduction in TEWL was observed following the fifth instance of hand washing. This remarkable decline in TEWL signifies that the coconut-derived antimicrobial active plays a pivotal role in enhancing the skin’s natural barrier function. By fortifying the skin barrier, this active ingredient aids in preventing excessive water loss, thereby improving overall skin moisture levels. The substantial drop in TEWL observed with the inclusion of the coconut-derived antimicrobial active suggests its potential to bolster the skin’s resilience to moisture loss. This finding punctuates its beneficial impact on skin health, particularly in maintaining optimal hydration levels and reinforcing the skin’s ability to retain moisture. To conclude, the data strongly indicates that the incorporation of the coconut-derived
PERSONAL CARE October 2023
TABLE 2: SAMPLE FORMULATION OF AN ALCOHOL-FREE SANITIZER
Ingredients /INCI Water
NatPro 8000
PEG-40 Hydrogenated Castor Oil Fragrance TOTAL
% w/w q.s.
1.25% 1.35% 0.10% 100%
Procedure: Load NatPro 8000, PEG-40 Hydrogenated Castor Oil and the fragrance in a clean container. Homogenize the bulk. Load Water in the container. Mix until a translucent consistency is obtained.
antimicrobial active into the soap formulation leads to a pronounced reduction in TEWL after repeated hand washing. This outcome supports the active’s ability to enhance the skin barrier, ultimately contributing to improved skin moisture retention. The findings hold promising implications for the formulation of skincare products aimed at preserving skin health and promoting enhanced hydration.
Coconut-derived antimicrobial active for alcohol-free sanitizer The effectiveness of the coconut-derived antimicrobial active in alcohol-free hand sanitizers was investigated through a comprehensive study. The research aimed to assess its antimicrobial capabilities by examining its impact on various bacteria commonly present on hands. The experimental process involved baseline
swabbing of participants’ hands, followed by inoculating the swab samples onto blood agar plates and MacConkey agar plates for differentiation of gram-negative organisms. Subjects were then asked to use a 1%
solution of the coconut-derived antimicrobial active to sanitize their hands. Subsequent swab samples were taken and plated at different time intervals: immediately after sanitation, 15 minutes, one hour, two hours and four hours later. Replicates were plated and incubated for 24 hours to evaluate the active’s antimicrobial properties. The results yielded significant insights. The
coconut-derived antimicrobial active exhibited the capacity to eliminate bacterial loads on the hands. Notably, the 1% solution demonstrated a remarkable 100% bacterial kill rate. Notably, instances of Klebsiella pneumoniae and E. coli – known pathogens responsible for respiratory infections and diarrhea, respectively – were detected in some subjects. However, the coconut-derived antimicrobial active promptly eradicated these harmful microorganisms, offering immediate protection. The study concluded that even at a low
concentration of 1%, the coconut-derived antimicrobial active displayed excellent sanitizing capabilities. This was evidenced by its consistent 100% bacterial kill rate across various time intervals up to 4 hours post- treatment, compared to baseline cultures. These findings highlight the active’s potent efficacy as a highly effective hand sanitizer, showcasing its ability to counteract bacterial contamination and contribute to improved hand hygiene. Lastly, the research highlights the
coconut-derived antimicrobial active’s remarkable potential as an exceptional antibacterial agent in alcohol-free hand sanitizers. Its ability to achieve a 100% bacterial kill rate and swiftly eliminate harmful pathogens reinforces its efficacy as a robust and reliable solution for maintaining hand hygiene and safeguarding against microbial threats.
Conclusion In this day and age of hygiene and sustainability, NatPro 8000 demonstrates nature’s potential in addressing these challenges. With a commitment to safety, efficacy, and
environmental responsibility, this coconut- derived antimicrobial active paves the way for a new preservation era. It upholds consumer wellbeing and product integrity while resonating with evolving demands.
PC
www.personalcaremagazine.com
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108
