NATURALS
Unlocking the power of serene sage
Anne-Laure Larrivière - Naolys
The field of skincare has experienced a revolutionary shift in recent years with the discovery of the skin microbiome and its crucial role in maintaining skin health. The skin microbiome, consisting of a diverse community of microorganisms, plays a pivotal role in maintaining skin health and protecting against external aggressors. The epidermal defence mechanisms
encompass three lines of defence: physical, chemical, and immune, which work in tandem to safeguard the skin. This skincare active strengthens these defence mechanisms to reinforce the cutaneous barrier and optimize the skin’s overall wellbeing. Naolys, a passionate advocate for the
environment and the healing properties of plants, has harnessed the power of natural botanicals and advanced biotechnology to create Serene Skin Sage. This innovative skincare active leverages the potential of the skin microbiome to enhance the skin’s defences and promote a radiant and soothed complexion. It strengthens the skin’s defence mechanisms to reinforce the cutaneous barrier and optimize the skin’s overall wellbeing. Through comprehensive in vitro and clinical testing, the remarkable benefits of Serene Skin Sage have been validated, providing a breakthrough in the realm of skincare. In Naolys’ botanical product portfolio, sage stands out as a key botanical ingredient due to its rich history and scientifically substantiated medicinal properties. By harnessing the power of this remarkable plant through advanced biotechnology, Naolys brings forth its potent benefits in skincare formulations, offering a harmonious fusion of nature and innovation.
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Sage: a medicinal marvel Sage (Salvia officinalis) is an exceptional plant, originating from the Mediterranean’s dry regions, has captured attention for its remarkable therapeutic properties. With a rich history dating back centuries, sage has earned its place in the annals of traditional medicine, being recognized for its antiseptic, tonic, and soothing effects on mucous membranes, as well as its digestive benefits.1-3 Scientific studies have substantiated its medicinal attributes, cementing its position as a trusted botanical remedy.
Triple reinforcement of the cutaneous barrier The skincare active has demonstrated a wide-
+17% +20% +25%
ranging activation of the skin barrier, leading to a reconstructing effect. Scientific studies have been conducted to investigate the effects of the skincare active on cell differentiation at different stages. Specifically, a study focused on the basal layer of the skin and examined the expression of the differentiation marker Ki-67. The results of the study revealed a significant stimulation of proliferation in basal layer keratinocytes when exposed to the skincare active. This effect was assessed through immunohistological analysis, specifically by measuring the Ki-67. The analysis showed that the number of labeled cells increased by 17%, 20%, and 25% respectively compared to the untreated control group. These findings indicate a positive impact
on cell differentiation in the basal layer of the skin, promoting increased proliferation of keratinocytes. This enhanced cell growth may contribute to the overall rejuvenating and revitalizing effects of the skincare active on the skin. At concentrations of 0.5%, 1% and 2.5%, the
0.5% 1% 2.5% Figure 1: Number of KI-67 labelled cells based on concentration of the skincare active 0.5%, 1%, 2.5%
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skincare active stimulated the proliferation of keratinocytes in the basal layer by 17%, 20% and 25% respectively. This stimulation of cellular renewal contributes to a more youthful and revitalized complexion, promoting a smoother skin texture and reducing the appearance of fine lines and wrinkles. By evaluating the mitotic index through immunohistochemical staining of Ki-67, researchers gained insights into the rate of
October 2023 PERSONAL CARE
Number of labelled cells (KI-67)
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