SUN CARE Placebo Cream ■ GMB Cream ■
57 56 55 54 53 52 51 50
0 Time (month)
Figure 4: The individual typology angle (ITA) before and after three months of applying either 0.005% GMB or a placebo. The lower the ITA, the more the skin is tanned. GMB allows you to maintain a tan for three months after acquiring your tan
As described above, these proteins motivate the melanocyte to produce protective melanin, even when UV light is limited. Twenty-two volunteers were monitored to
evaluate the rate and intensity of tanning. The use of 0.06% GMB was compared to a placebo. An astonishing 90% of the volunteers stated to tan two days faster with GMB compared to the placebo. Moreover, it was clear that the GMB lead to more intense tanning. The GMB-treated skin was significantly darker for the majority of participants (Figure 2). The study also tested how long the tan
3
100 90 80 70 60 50 40 30 20 10 0
-GMB; -UV +GMB, -UV +GMB, +UV
Figure 5: MMP1 gene expression measured in the presence/absence of UV light and the presence/absence of 0.06% GMB. The higher the percentage of gene expression, the more MMP is active. The plot shows that MMP is less present when applying GMB. In other words, the quality of collagen is improved in the skin because MMP does not have to clean bad collagen
persisted. When the participants stopped using the 0.06% GMB treatment, they all experienced a tan that was still present ten days longer than the placebo treatment (Figure 3). The ultimate strength of GMB is that the
tan persists over a long period. The individual typology angle (ITA) was measured before and after a three-month 0.005% GMB daily treatment for 37 people. The ITA is a measurement for skin darkness; the darker the skin, the lower the ITA.1 After three months, the ITA was still at the level as before the study (Figure 4). Thus, it is
still possible to maintain a tan that was acquired in summer until the Christmas dinner party.
Premature skin ageing UV irradiation leads to premature skin ageing because of the generation of an excess of destructive ROS.2,3
45
This ROS destroys collagen
fibres. Collagen is the main support of the skin. All this deteriorated collagen needs to be
cleaned away. This cleaning job is performed by the enzyme matrix metalloproteinase (MMP). More collagen destruction needs more cleaning up. This leads to a higher production of MMP.
www.personalcaremagazine.com
October 2023 PERSONAL CARE
Fading Skin Colour (%)
MMP1 gene expression (%)
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108
