MARINE INGREDIENTS
71
2.5 2 1.5 1 -35.1 %*
Day 0
Day 30
0.5 0 T0 T30
Average score of dermatologist based on IGA score (n=6). pvalue = 0.008
Figure 5: Investigator global assessment on inflammatory reduction Skin samples were treated with a cream
containing either 3% natural origin omega-3 delivery system or the microalgae extracts* and incubated for 24 hours. Samples were then incubated for 30 minutes with DCFH- DA at 40°C, a fluorescent marker that reacts with ROS. Samples were then irradiated with UV-Vis at 500 W/m2
for 30 minutes. Samples
were observed by optical microscopy using fluorescence filters to show and quantify ROS presence. Microalgae extracts were incorporated
into cream at use levels that would be found in 3% natural origin delivery system The results show that N. gaditana and I. galbana extracts alone were able to reduce the amount of ROS generated by 39%, where the N. gaditana and I. galbana extracts that were in a double-encapsulated Bicosome were able to reduce ROS generation even further, by 124% (Figure 4). These results show both the effect that the N. gaditana and I. galbana extracts have in ROS reduction as well as the Bicosome’s role in keeping the microalgae actives protected and delivering them to the epidermis where they can be most effective.
0.50 0.45 0.40 0.35 0.30
0.25 0.20
Day 0 Day 14 Day 28 Day 56
Average results of FRAP enzymatic reaction ± SE in different experimental times (n=20, * = p value <0.05).
Figure 6: Increase of antioxidant capacity (left) & reduction of lipid peroxidation (right)
www.personalcaremagazine.com October 2021 PERSONAL CARE 0.125 0.100 Day 0 Day 14 Day 28 Day 56
Average results of MAD enzymatic reaction using TBA ± SE in different experimental times (n=20, * = p value <0.05).
* 0.175
67% average increase of
antioxidant capacity 0.155
Natural origin omega-3 delivery system – in vivo study A study was conducted with 20 adult volunteers, averaging 36 years old, all with chronic mild to moderate inflammatory acne and/or rosacea. Participants used a cream containing natural origin omega-3 delivery system at 3% twice a day over 30 days and the following measurements were carried out at 0 and 30 days under dermatological control. Visia® was used to evaluate changes in skin colour hyperpigmentation (freckles, melasma), red areas (vascular disorders due to acne, rosacea, spider veins, inflammation, presence of large pores and porphyrins), at the beginning and end of the study. Clinical evaluation, patient self-assessment and aesthetic evaluation of product in formulation was also performed. Results of the study are in Figure 5, demonstrating natural origin omega-3 delivery system’s capability to mitigate common skin conditions linked to chronically inflamed skin. Please reach out to the authors for complete in vivo results.
Natural origin delivery system Bicoalgae XT, is a natural origin carotenoid rich delivery system that has targeted delivery of
* 0.225 0.200 * 26% average
reduction lipid peroxidation
*
carotenoid rich algae, H. Pluvialis to specific skin layers. Carotenoids include lutein, canthaxanthin, zeaxanthin, β-carotene and astaxanthin. Astaxanthin is 65 times more powerful than vitamin C, 54 times more potent than β-carotene, and offers 100 times the efficacy of β-tocopherol.6
Bicoalgae® XT (now
referred to as ‘natural origin carotenoid-rich delivery system’) provides clinically proven anti- ageing benefits and has a double encapsulation which provides stabilisation of the active and protection against degradation.
Studies A study was performed with 20 female volunteers, 35-55 years old, with different skin types where they used a cream containing 3% natural origin carotenoid-rich delivery system as the sole active ingredient twice a day for 56 days. Measurements were recorded at 0, 14, 28
and 56 days under dermatological control where the focus was on antioxidant capacity, epidermis cell renewal, brightness, epidermal water loss, firmness, and wrinkles. Select results are in Figure 6 and Figure 7; please reach out to the authors for complete results.
FRAP
TBA
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