MARINE INGREDIENTS
angiogenesis occurs, and keratinocytes proliferate and migrate to close the wound. In the final tissue-remodelling phase, apoptosis eliminates myofibroblasts and extraneous blood vessels, and the ECM is remodelled to resemble the original tissue. Fibrosis or scarring occurs when
inappropriate tissue remodelling results in excess ECM deposition due to myofibroblast survival or lack of ECM proteolytic degradation. At the other extreme of wound healing pathophysiology, chronic wounds feature dysregulated tissue remodelling with enhanced ECM degradation. As wound healing and its dysregulation via fibrosis and other means occur in all tissues, analysis of these mechanisms may yield novel repair and regenerative treatments for a variety of disorders. In this study we looked at 84 key genes
central to the wound healing response, allowing us to reliably analyse the tempero-spatial expression of a focused panel of genes involved in wound healing, tissue injury and repair, and highlighting many genes with skin-relevant functions whose expression is regulated by the Marine Magnesium Mineral Extract.
Gelest 3ChAd 20.qxp_Layout 1 10/09/2021 10:51 Page 1
Conclusion Dr. Murphy’s work has repeatedly shown that marine sourced minerals in the form of this unique liquid Marine Magnesium Mineral Extract are far superior to traditional minerals in stability, bioavailability and overall bio- functionality. This form of marine mineral is, in fact, so much more efficient that we have repeatedly demonstrated in human skin trials that they can be taken at significantly lower levels than their earth-sourced counterpart without compromising efficacy, health benefits and performance. One emerging new frontier in science is
how magnesium affects the microbiome. The link between magnesium status, and both gut
Around 40% of all the magnesium in our
body exists within cells and soft tissue, while 60% is in our teeth and bones, and less than 1% circulates in our blood. Because of its vital intracellular work, magnesium is crucial to our overall physical, emotional health and well- being, with every physiological system and organ, including our skin and microbiomes, rely on magnesium to function optimally.
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PC
References 1. Proksch E., Nissen H.P., Bremgartner M., Urquhart C. Bathing in a magnesium rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin. International Journal of Dermatology 2005; 44 (2):151–157
2. Schempp C.M., Dittmar H.C., Hummler D., et al. Magnesium ions inhibit the antigen-presenting function of human epidermal Langerhans cells in vivo and in vitro. Involvement of ATPase, HLA-DR, B7 molecules, and cytokines. Journal of Investigative Dermatology 2000; 115 (4):680–686
and skin health is gaining traction with the exponential increase in scientific studies on this topic. As scientists continue to learn more and more about how important our gut and skin microbiome is to our overall physical and mental health, they are able to determine how individual nutrients, like magnesium impact our microbial mix and the direct positive effect on our friendly biota, both skin and gut. As the fourth most abundant mineral in the human body, magnesium is a cofactor in over 600 enzyme-driven biochemical reactions, playing a crucial role in most of our major bodily processes, from regulating blood pressure, muscle and nerve function to supporting DNA and RNA synthesis, producing energy within cells, balancing electrolytes and regulating the hormonal (endocrine) system.
3. Greiner J., Diezel W. Inflammation-inhibiting effect of magnesium ions in contact eczema reactions. Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete 1990; 41 (11):602
4. Yoshizawa Y., Tanojo H., Kim S.J., Maibach H.I. Sea water or its components alter experimental irritant dermatitis in man. Skin Research & Technology 2001; 7 (1):36–39
5. Duffy E., De Guzman K., Wallace R., et al. Non- Invasive Assessment of Skin Barrier Properties: Investigating Emerging Tools for In Vitro and In Vivo Applications. Cosmetics 2017; 4(4): 44
6. Wallace R., Kenealy M.R., Brady A., et al. 2020 Development of dynamic cell and organotypic skin models, for the investigation of a novel visco-elastic burns treatment using molecular and cellular approaches.
https://doi.org/10.1016/ j.burns.2020.04.036
www.personalcaremagazine.com
October 2021 PERSONAL CARE
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