SKIN CARE T0 Before exposure to cold Placebo T15min After exposure to cold 2.5% Neurofense
63
Skin redness: - Figure 4: Study of redness on skin reactive to cold
on these three biological components, thereby augmenting unpleasant sensations.11,12,13,14,15,16,17 Concerning ethnicity-related differences, it has also been demonstrated that Asian skin is more subject to aggressions than Caucasian or Afro- American skin.18,19,20 With the development of novel models in vivo
on two Caucasian panels, Silab has demonstrated the soothing efficacy of its natural active ingredient in extreme situations. When stressed by cold, it increases the reactivity threshold of skin in conditions mimicking winter climate, on the face (+7.5%, P < 0.001) and hands (+15.5%, P < 0.05). It also attenuates the reactivity of skin to cold by decreasing the appearance of skin redness (-43%, P = 0.0005) (Figure 4). Besides, in environmental (pollution) and chemical stress conditions, the Salvia miltiorrhiza active reduces the neuronal hyper-reactivity, by significantly limiting the skin sensitivity to capsaicin by 38%. Volunteers themselves confirmed these results
after 14 days of application of the active ingredient to the face and hands (Figure 5). On the face, 83% of volunteers consider that sensations of tightness were reduced (compared to only 61% for the placebo) and skin discomfort was lower for 94% of them (compared to only 67% for the placebo). These data apply also on the hands since 92% of the volunteers reported that
their hands were protected (compared to 62% for the placebo) and that the product is a soothing care (compared to 46% for the placebo). In addition, a study was conducted in China
by the Shanghai Skin Disease Hospital on Asian volunteers, declaring to have sensitive skin and having been exposed to urban pollution for at least one year before the study began. The test conducted with a Neurometer® CPT on the face demonstrated the capacity of the natural active to reduce sensitivity to pollution in Asian skin (-19%, P < 0.05). In addition, a consumer test was conducted
to compare the efficacy of a care product containing the Salvia miltiorrhiza active formulated at 2.5% in an emulsified gel to its placebo. Evaluations were conducted on Asian volunteers at the end of the first day of the test and after 14 days of twice daily application, using self-evaluation questionnaires. Overall, women having used the formula
containing the Salvia miltiorrhiza active attributed better results to the questionnaire items than those having used the placebo formula: more women reported an attenuation of skin redness (94% compared to 87% for the placebo) and agree that their skin is less irritable (89% compared to 83% for the placebo).
Total ‘agree’ and ‘mostly agree’ responses (%) Face Skin discomfort reduced (*) Sensations of tightness reduced (*) Hands Soothing care product (***) Hands protected (**) 46 62 2.5% Neurofense ■ Placebo ■
*** Significant differences /placebo (P < 0.001) ** Significant differences /placebo (P < 0.01) * Significant differences /placebo (P < 0.05)
Figure 5: Self-evaluation of Neurofense by Caucasian volunteers
www.personalcaremagazine.com 61
92 92
94 67 83 Thanks to its multiethnic efficacy, the
Salvia miltiorrhiza active restores protection to both Caucasian and Asian sensitive skin and offers an overall solution taking lifestyle into account.
Conclusion Neurofense® is the first natural neuro-soothing concentrate of the cosmetics industry. A patented, safe, and biodegradable natural active ingredient, it is compliant with international cosmetic regulations. Substantiated through novel and robust in vitro and in vivo research studies, it is an effective innovative solution for products embodying the promise of renewed comfort for sensitive skin.
PC
References 1. Draelos ZD. Am. J. Contact Dermat. Off J. Am. Contact Dermat. Soc. 1997; 8(2)
2. Misery et al. J Eur. Acad. Dermatol. Venereol. JEADV. 2016.; 30 Suppl 1
3. Duarte et al. An. Bras. Dermatol. 2017; 92(4) 4. Berardesca et al. Int. J. Cosmet. Sci. 2013; 35(1) 5. Misery L. Clin. Dermatol. 2017; 35(3) 6. Gouin et al. Protein Cell. 2017 ; 3 7. Saint-Martory et al. Br. J. Dermatol. 2008;158(1) 8. Pinto et al. Skin Res. Technol. Off J. Int. Soc. Bioeng. Skin ISBS Int. Soc. Digit Imaging Skin ISDIS Int. Soc. Skin Imaging ISSI. 2011; 17(2)
9. Richters et al. Skin Pharmacol. Physiol. 2017; 30(1) 10. Tóth et al. Br J Pharmacol. 2014; 171(10) 11. Aubdool et al. J. Investig. Dermatol. Symp. Proc. 2011.; 15(1)
12. Fariss et al. Toxicol Sci. Off J. Soc. Toxicol. 2013; 132(2)
13. McKemy DD. ACS Chem. Neurosci. 2013; 20; 4(2). 14. Mancebo et al. J. Eur. Acad. Dermatol. Venereol. JEADV. 2015; 29(12)
15. Engebretsen et al. J. Eur. Acad. Dermatol. Venereol. JEADV. 2016 Feb.; 30(2).
16. Lee et al. Sci. Rep. 2016 June 17; 6. 17. Li et al. Int. J. Environ. Res. Public Health. 2017; 12; 14(1)
18 Modjtahedi et al. Contact Dermatitis. 2002 ; 47(5)
19. Lev-Tov et al. Indian J. Dermatol. 2012.; 57(6). 20. Lee et al. Skin Res. Technol. Off J. Int. Soc. Bioeng. Skin ISBS Int. Soc. Digit Imaging Skin ISDIS Int. Soc. Skin Imaging ISSI. 2014; 20(3)
* Yuecheng Li, Head Pharmacist of the Sichuan Food and Drug Inspection and Test Institute
October 2021 PERSONAL CARE
Skin redness: ++
Skin redness: +
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92
