ANTI-AGEING A
110 105 100 95 90 85
B
110 105 100 95 90 85
CHANGE IN CROW’S FEET OF A MAN IN HIS 60S Placebo lotion
67
**
1% PME lotion **: p<0.05 vs.0 week
0 week 4 week 12 week Placebo lotion ** 1% PME lotion **: p<0.05 0 week 4 week 12 week 0 week 4 weeks 12 weeks
Figure 6: Effects of PME on crow’s feet & neck wrinkles The analysis of crow’s feet is shown in Figure 6A. The analysis of neck wrinkle is shown in Figure 6B. The results are expressed as mean ±S.E. (N=14, Student’s t-test, **p<0.05, ##: p<0.05)
condition of dermal thinning caused by natural ageing or environmental stress. As the wrinkle improvement effect has also been confirmed in the test, the effect in terms of improving the skin-thinning condition utilising the dermal thinning mechanism clarified by this study will be an effective approach to reducing wrinkles.
JII 3ChAd 20.qxp_Layout 1 13/09/2021 11:56 Page 1
Conclusion PME is an anti-ageing ingredient that prevents eATP-mediated dermal thinning caused by natural ageing or environmental stress and improves wrinkles in many areas. In addition, as it is a cosmetic ingredient listed in IECIC 2021
PC
and is compliant with the Japanese Standards of Quasi-Drug Ingredients, it is expected to be useful in various final products.
4. Yaniv Y, Juhaszova M, Sollott S J. Trends in Endocrinology & Metabolism 2013; 24: 495-505.
PC
References 1. Hatamochi A. Dokkyo Journal of Medical Sciences 2008; 35: 227-236. Kuwazuru O, et al. Japan National Congress of Theoretical and Applied Mechanics 2006; 55: 314.Kuwazuru O, et al. Seisankenkyu 2005; 57: 497.
2. Sottile J, et al. J. Cell Physiol 1989; 138: 281- 290. Hayakawa T, Motoyama N. Biomedical Gerontology 2011; 35: 29-31.
3. Salama R, et al. Genes Dev. 2014; 28(2): 99–114.
5. Zolkipli-Cunningham Z, Falk MJ. Toxicology 2017; 391: 90-99.
5. Kawano A, et al. PLoS One 2015; 10(6) e0127919. 6. Ohara H, et al. J. Dermatol. Sci. 2010; 58: 143-151. 7. Inoue K, Hosoi J, Denda1 M. J Invest Dermatol 2007; 127: 362-371. Sabirov RZ, et al. The EMBO Journal 2017; 36: 3309-3324.
8. Oike M, Droogmans G, Ito H. Folia Pharmacol. 2004; 123: 403-411.
9. Koizumi S. Annual Report of Cosmetology. Cosmetology2014; 22:
95-98.Geraghty NJ, et al. World Journal of Dermatology 2016; 5: 72-83.
CHANGE IN NECK WRINKLES OF A MAN IN HIS 40S 0 week 4 weeks 12 weeks
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October 2021 PERSONAL CARE
Depth relative value (%)
Depth relative value (%)
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