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oncolog-hematolog
ro
oncologie
unei colonoscopii pentru biopsie şi Tabelul 5
eventual polipectomie, iar acesta nu este
Recomandările ghidurilor oncologice pentru screening-ul cancerului colorectal
singurul dezavantaj al probei. Un altul
foarte important ar fi legat de costuri.
Anual, test fecal pentru hemoragii oculte pentru pacienţii >50 de ani
Studiile efectuate până în prezent în
Sigmoidoscopie la 5 ani pentru pacienţii >50 de ani
Europa şi SUA au arătat costurile ridicate
ale acestei tehnici şi rezultatele în pre-
Colonoscopie la 10 ani pentru pacienţii >50 de ani
venţie asemănătoare colonoscopiei cla-
sice. Un singur element este în favoarea iv. irigografia parte, din cauza scăderii numărului de
colonografiei şi acela se referă la com- Irigografia a reprezentat multă vreme specialişti - proba fiind dificilă şi ex­trem
plianţa crescută a pacienţilor în faţa tehnica cea mai importantă de diagnostic de iradiantă nu sunt tineri radiologi in-
unei probe care nu presupune nici un al cancerului colorectal. De cel puţin un teresaţi în a o efectua.
disconfort. Concluzia în momentul de deceniu însă, importanţa acestei probe Astăzi, irigografia nu este inclusă în pro-
faţă este că această investigaţie perfor- începe să scadă din cauza, pe de o parte, a gramul de screening al cancerului colorec-
mantă nu face parte din nici un program sensibilităţii scăzute faţă de colonoscopie tal, rămânând o investigaţie grosolană,
de screening în lume. în programele de screening şi, pe de altă pentru detectarea leziunilor avansate. n
Bibliografie
1. American Cancer Society. Cancer Facts & Figures 2004. Available at: http://www. Abstract.
cancer.org/downloads/STT/CAFF_finalPWSecured.pdf. Accessed August 4,
23. Sakakibara T., Nakamura T., Yamamoto M., Matsuo M. Microsatellite instability
2004.
in Japanese hereditary non-polyposis colorectal cancer does not induce muta-
2. Fearon E.R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;
tion of a simple repeat sequence of the bax gene. Cancer Lett. 1998;124:193-197.
61:759-767. Abstract.
3. Herrera L., Kakati S., Gibas L., Pietrzak E., Sandberg A.A. Gardner syndrome in
Abstract.
a man with an interstitial deletion of 5q. Am J Med Genet. 1986;25:473-476. Ab-
24. Rampino N., Yamamoto H., Ionov Y. et al. Somatic frameshift mutations in the
stract. BAX gene in colon cancers of the microsatellite mutator phenotype. Science.
4. Bodmer W.F., Bailey C.J., Bodmer J. et al. Localization of the gene for familial adeno- 1997;275:967-969. Abstract.
matous polyposis on chromosome 5. Nature. 1987;328:614-616. Abstract.
25. Giardiello F.M., Brensinger J.D., Tersmette A.C. et al. Very high risk of cancer in
5. Leppert M., Dobbs M., Scambler P. et al. The gene for familial polyposis coli maps
familial Peutz-Jeghers syndrome. Gastroenterology. 2000;119:1447-1453. Abstract.
to the long arm of chromosome 5. Science. 1987;238:1411-1413. Abstract.
6. Kinzler K.W., Nilbert M.C., Su L.K. et al. Identification of FAP locus genes from chro-
26. Jenne D.E., Reimann H. Nezu J. et al. Peutz-Jeghers syndrome is caused by muta-
mosome 5q21. Science. 1991;253:661-665. Abstract.
tions in a novel serine threonine kinase. Nat Genet. 1998;18:38-43. Abstract.
7. Nishisho I., Nakamura Y., Miyoshi Y. et al. Mutations of chromosome 5q21 genes in
27. Hemminki A., Markie D., Tomlinson I. et al. A serine/threonine kinase gene defec-
FAP and colorectal cancer patients. Science. 1991;253:665-669. Abstract. tive in Peutz-Jeghers syndrome. Nature. 1998;391:184-187. Abstract.
8. Groden J., Thliveris A., Samowitz W. et al. Identification and characterization of the
28. Gruber S.B., Entius M.M., Petersen G.M. et al. Pathogenesis of adenocarcinoma in
familial adenomatous polyposis coli gene. Cell. 1991;66:589-600. Abstract.
Peutz-Jeghers syndrome. Cancer Res. 1998;58:5267-5270. Abstract.
9. Miyoshi Y., Nagase H., Ando H. et al. Somatic mutations of the APC gene in colorec-
29. Howe J.R., Roth S., Ringold J.C. et al. Mutations in the SMAD4/DPC4 gene in juve-
tal tumors: mutation cluster region in the APC gene. Hum Mol Genet. 1992;1:229-
233. Abstract.
nile polyposis. Science. 1998;280:1086-1088. Abstract.
10. Ichii S., Horii A., Nakatsuru S. et al. Inactivation of both APC alleles in an early
30. Olschwang S., Serova-Sinilnikova O.M., Lenoir G.M., Thomas G. PTEN germ-line
stage of colon adenomas in a patient with familial adenomatous polyposis (FAP). mutations in juvenile polyposis coli. Nat Genet. 1998;18:12-14. Abstract.
Hum Mol Genet. 1992;1:387-390. Abstract.
31. Liaw D., Marsh D.J., Li J. et al. Germline mutations of the PTEN gene in Cowden
11. Levy D.B, Smith K.J., Beazer-Barclay Y., Hamilton S.R., Vogelstein B., Kinzler
disease, an inherited breast and thyroid cancer syndrome. Nat Genet. 1998;16:64-
K.W. Inactivation of both APC alleles in human and mouse tumors. Cancer Res.
67.
1994;54:5953-5958. Abstract.
12. Knudson A.G. Antioncogenes and human cancer. Proc Natl Acad Sci U S A.
32. Marsh D.J., Dahia P.L., Zheng Z. et al. Germline mutations in PTEN are present in
1993;90:10914-10921. Abstract.
Bannayan-Zonana syndrome. Nat Genet. 1997;16:333-334. Abstract.
13. Aaltonen L.A., Peltomaki P., Leach F.S. et al. Clues to the pathogenesis of familial
33. Laken S.J., Petersen G.M., Gruber S.B. et al. Familial colorectal cancer in Ashke-
colorectal cancer. Science. 1993;260:812-816. Abstract. nazim due to a hypermutable tract in APC. Nat Genet. 1997;17:79-83. Abstract.
14. Kinzler K.W., Vogelstein B. Lessons from hereditary colorectal cancer. Cell.
34. Rozen P., Shomrat R., Strul H. et al. Prevalence of the I1307K APC gene variant in
1996;87:159-170. Abstract.
Israeli Jews of differing ethnic origin and risk for colorectal cancer. Gastroenterol-
15. Spirio L., Olschwang S., Groden J. et al. Alleles of the APC gene: an attenuated form
of familial polyposis. Cell. 1993;75:951-957. Abstract.
ogy. 1999;116:54-57. Abstract.
16. Ahlquist D.A. Aggressive polyps in hereditary nonpolyposis colorectal cancer:
35. Sieber O.M., Lipton L., Crabtree M. et al. Multiple colorectal adenomas, clas-
targets for screening. Gastroenterology. 1995;108:1590-1592. Abstract.
sic adenomatous polyposis, and germ-line mutations in MYH. N Engl J Med.
17. Rijcken F.E., Hollema H., Kleibeuker J.H. Proximal adenomas in hereditary non- 2003;348:791-799. Abstract.
polyposis colorectal cancer are prone to rapid malignant transformation. Gut.
36. Lipton L., Halford S.E., Johnson V. et al. Carcinogenesis in MYH-associated polyp-
2002;50:382-386. Abstract.
osis follows a distinct genetic pathway. Cancer Res. 2003;63:7595-7599. Abstract.
18. Syngal S., Fox E.A., Eng C., Kolodner R.D., Garber J.E. Sensitivity and specificity of
37. Halford S.E., Rowan A.J., Lipton L. et al. Germline mutations but not somatic
clinical criteria for hereditary non-polyposis colorectal cancer associated muta-
tions in MSH2 and MLH1. J Med Genet. 2000;37:641-645. Abstract.
changes at the MYH locus contribute to the pathogenesis of unselected colorectal
19. Peltomaki P. DNA mismatch repair and cancer. Mutat Res. 2001;488;77-85. Ab-
cancers. Am J Pathol. 2003;162:1545-1548. Abstract.
stract. 38. Giardiello F.M., Brensinger J.D., Petersen G.M. et al. The use and interpretation of
20. Markowitz S., Wang J., Myeroff L. et al. Inactivation of the type II TGF-beta re- commercial APC gene testing for familial adenomatous polyposis. N Engl J Med.
ceptor in colon cancer cells with microsatellite instability. Science. 1995; 268:1336-
1997;336:823-827. Abstract.
1338. Abstract.
39. Umar A., Risinger J.I., Hawk E.T., Barrett J.C. Testing guidelines for hereditary non-
21. Parsons R., Myeroff L.L., Liu B. et al. Microsatellite instability and mutations of the
transforming growth factor beta type II receptor gene in colorectal cancer. Cancer
polyposis colorectal cancer. Nat Rev Cancer. 2004;4:153-158. Abstract.
Res. 1995;55:5548-5550. Abstract.
40. Frazier M.L., Su L.K., Amos C.I., Lynch P.M. Current applications of genetic tech-
22. Souza R.F., Appel R., Yin J. et al. Microsatellite instability in the insulin-like growth
nology in predisposition testing and microsatellite instability assays. J Clin Oncol.
factor II receptor gene in gastrointestinal tumours. Nat Genet. 1996;14:255-257. 2000;18:70S-74S. Abstract.
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