MARINE INGREDIENTS


140 120 100 80 60 40 20 0


02 4 Days


Figure 4: Dry HPDR in a water-saturated atmosphere.


Natural active against UV rays In addition to its biological effects, the integral DNA molecule has an important physical characteristic: the partial protection against the diffusion of UV radiation. When applied very thinly (1 mm), a 1% integral DNA solution absorbs all weak intensity UV rays between a 200 mm and 300 mm wavelength (Fig. 1).1,2


by remedying the deficiencies in the barrier effectiveness of solar filtering and preventing and curing the eventual damage caused by UV rays to the skin. Further, its moisturising and antioxidant activity will allow safe sun tanning. In addition, integral DNA depolymerises but does not form toxic breakdown products. In view of the ageing phenomenon by exposure to UV solar rays, the cellular DNA of the epidermis undergoes damage for the same reason. The protective application of DNA in a gel form captures the nocuous UV rays and so protects the cell nucleus within the skin.


DNA, placed on the skin surface, will be able to block out part of the UV ray diffusion to the skin (the same wavelength that destroys the DNA cell). The addition of integral DNA in a sun care product enhances its photo-protective action (Fig. 2),3


Antioxidant activity An antioxidising activity (Fig. 3)4


with the trapping of OH• radicals within the double helix, (this activity improves the effects of alpha tocopherol). In addition to this free radical scavenging activity, the integral DNA biomolecule presents another advantage in comparison with most other substances of the same activity. After scavenging free radicals, it does not form new toxic derived radicals that are able to damage other neighbouring components (the attack of OH• radicals upon integral


takes place 6 8 10 40 30 20 10 0


012 3 Days of treatment with HPDR (2.5% gel)


4 Figure 5: Estimated moisturising power of the HPDR gel on the skin aspect of 10 women.


DNA proceeds by addition and gives 8-OH deoxyguanosine). Rates of reactions in polymerised molecules have been reported.5 By evaluation of the expression of several genes by microcomputer-chips with DNA (cDNA-array gene expression) on normal human keratinocytes,6


we recorded


an activation of several genes (TFRC, +4812% –FTH1, +153%); activation of the ferritin and the transferrin receptor. Integral DNA has an effect of protection against the toxicity of iron in the scavenging reactions (ROS – reactive oxygen species). For example, after UV exposure, the


Integral


100 90 80 70 60 50 40 30 20 10 0


■ Smoothness ■ Softness ■ Suppleness


quantity of ferritin increases to complex iron and thus avoids its catalyst effect on free radicals.


Rebuilding of the cutaneaous damage By evaluation using the same cDNA-array gene expression on normal human keratinocytes,6


we recorded an activation


of several genes (CRNN, +335% –RPTN, +255% –TNF, +225% –SFN, +247%). Cornulin is a (cornified) stratified squamous epithelial protein that is considered a marker of late keratinocyte differentiation. The repetin is necessary to


■ Cracked ■ Dry


12 3


4


5


6


7 Days of treatment with HPDR (2.5% gel) Figure 6: Moisturising power of the HPDR gel on the skin touch of 10 women.


7 6 5 4 3 2 1 0


8


9


10


■ Arachidonic acid 2.5 10–3


M) ■ Arachidonic acid HPDR 90 µg/mL


02


46 Days Figure 7: Study of protective effect of HPDR against lipid peroxydation. April 2012 PERSONAL CARE 59


8


Weight (water retention) g/100g of HPDR


Measurement of conjugated dienes OD 234 nm


Skin touch


Skin aspect


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