ACTIVES
Figure 4: Triglyceride stock at T0 (left), and after treatment with Phytosonic.
essential for optimum maintenance of the outer skin layer. This confirms the findings of the volunteer study where in particular among people with thin, fragile skin the skin’s resistance was clearly increased. A gene activation profile can also be carried out on the adipocytes. For the slimming active, Phytosonic, interesting properties are found that reflect the extensive product efficacy. For an increase in lipid breakdown a continuous metabolic action in the mitochondria is required, and in which carnitine is involved. The genes
which code for carnitine are clearly activated. The whole metabolism also requires a continuous energy supply. This function too is stimulated in the DNA array, as is the protection of cells from oxidative stress. Furthermore, a specific enzyme is activated which releases the adipocytes from its matrix, effectively isolates them and so prevents the lipids from bonding in place (Fig. 4). All of these actions were reproduced in vitro. In the application study the circumference of the upper thigh was on average reduced by 1 cm
and the skin smoothing effect was noticed by the test volunteers.
Conclusion
In conclusion, evidence based cosmetics require careful choice of tools, protocols, material. This general overview shows how broad the activity spectrum, which can be identified by cosmetogenomics, really is. Today’s claims need more than a corneometer study on three lab technicians, and cosmetogenics is the alternative to consider.
PC
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April 2012 PERSONAL CARE
137
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