UPCYCLED INGREDIENTS Control â–  0.33% Chios mandarin extract â– 


120 100 80 60 40 20 0


*p<0.05 versus untreated control **p<0.05 versus stressed control


Figure 5: Improved Procollagen I secretion and production of newly formed collagen In a second assay, dermal fibroblasts were


treated with the secretion of UV-stressed keratinocytes to simulate inflammaging conditions, in the presence and absence of the Chios mandarin extract. Again, analysis of genes showed that the inflammatory response was reduced by treatment with Chios mandarin extract representing an anti- inflammatory effect (Figure 4). Since the inflammatory response was


reduced in keratinocytes and dermal fibroblasts, we wanted to test whether Chios mandarin extract influenced collagen expression and deposition. Therefore, dermal fibroblasts were stressed with H2


O2 in the


presence or absence of Chios mandarin extract. Oxidative stress decreased the secretion


of procollagen I whereas treatment with Chios mandarin extract counteracted this effect and increased procollagen I release compared with the stressed control.


Placebo â–  2% Chios mandarin active â–  0 Before After 28 days Young collagen â–  Mature collagen â–  Placebo 1% Chios mandarin extract


55


-5


-10


-15


-20 7 days 28 days *p<0.0001 versus initial conditions Figure 6: Reduction of skin redness


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Procollagen I secretion compared to untreated control in %


Oxidative stress


Change in skin redness compared to initial conditions in %


* * *


* **


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