ANTI-POLLUTION 31 300000 250000 200000 150000 100000 50000 0 Control


Urban dust S.C 0.01% + Urban dust


Figure 2: Nrf2 cytoplasm expression after urban dust exposure or co-treatment with urban dust and Schisandra chinensis (S.C.) extract.


cytoplasmic (+15%, p<0.001) and nucleus (+28%, p<0.001) expression. The co-treatment demonstrated a higher cytoplasmic activity on Nrf2 (Fig 2) and a significant decrease in nucleus activity (-12%, p< 0.001), when compared with urban dust alone. DJ-1 cytoplasmic (+91%, p<0.001) and nucleus (+47%, p<0.001) expression increased in NHEK exposed to urban dust, when compared to control. Co-treatment induced a higher cytoplasmic expression when compared to urban dust alone


14000 12000 10000 80000 60000 40000 20000 0


Control ***


Urban dust S.C 0.01% + Urban dust


Figure 3: AhR cytoplasm expression after urban dust exposure or co-treatment with urban dust and Schisandra chinensis (S.C.) extract. *** p< 0.001 versus urban dust.


(+33%: p< 0.001). However, DJ-1 nucleus activity decreased after co-treatment. Urban dust induced the expression of AhR in cells. In fact, the presence of AhR increases in both cytoplasm (+42%, p<0.001) and nucleus (+44%, p<0.001) (Fig 3). Co-treatment induced a return to basal values (control).


Clinical study


Skin hydration was measured via capacitance measurements. The


4.50 4.00 3.50 3.00 2.50 2.00 1.50 1.00 0.50 0.00


n Placebo n Urbalys


***


D14


D21


Figure 4: Evolution of skin radiance between Schisandra chinensis extract named Urbalys® and placebo. Statistical significance *** p<0.001.


1%


measurable capacitance is mainly contributed by the stratum corneum water which is directly proportional to its water content. Treatment with S. chinensis induced a significant increase in skin hydration about 25% (p< 0.01) and 34% (p<0.001) respectively at D14 and D21 compared to placebo. We observed that treatment with S. chinensis increases the radiance of the skin by 19% and 47% (p< 0.001) respectively at D14 and D21 (Fig 4).


November 2018


PERSONAL CARE EUROPE


Nrf2 cytoplasm expression (Fluorescence intensity)


AhR cytoplasm expression (Fluorescence intensity)


Evolution of skin radiance


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