ORL
ro
ship between S-100 protein and prog- hans cells by immunohistochemical ate density of Langerhans cells and of
nosis of laryngeal carcinoma. S-100 methods using polyclonal antibodies marked lymphoid inflammation may
protein was observed by immunohis- against S100 protein and lysozyme. be considered favorable prognostic
tochemical methods using anti-S-100 Granulocytic and lymphoid inflamma- factors for patients with squamous
protein antibody in 68 laryngeal car- tory infiltration and its relationship to cell carcinoma of the larynx (21).
cinoma and 21 non-cancer laryngeal the presence of Langerhans cells were
tissues. The result showed that S-100 also evaluated. Langerhans cells were Conclusions
protein positive were found in 43 present within the cancer tissues and Laryngeal tumour APC study reveals
(63.24%) from 68 laryngeal carcinoma. showed a relationship with lymphoid that S100 protein positive cells were
S-100 protein positive cells were inter- infiltrate. No significant correlation identified in tumour area with squa-
spersed among the tumor cells and in was present among the density of Lang- mous differentiation in all cases, and in
the stroma. S-100 protein was rare in erhans cells and the site of neoplastic peritumour area in 41 cases (83,67%);
non-cancer laryngeal tissues. The five- growth, granulocytic inflammatory there is no correlation between S100
year survival rate in patients with S- infiltration, histological tumor grade, protein positive cell density and inva-
100 protein positive was significantly or clinical stage. Patients with high or sion level, but with grading. The pres-
higher than that in patients with S-100 intermediate density of Langerhans ence of S100 protein positive cells may
protein negative. Their results indicated cells survived longer than those with be considered a favourable prognostic
that the detection of S-100 protein is of low density (mean survival, 61%, 62%, element. Poor differentiate tumours
value for the prognostic analysis in pa- and 0%, respectively). The number of are associated with an increased num-
tients with laryngeal carcinoma (20). Langerhans cells was relevant in pa- ber of tumour area S100 protein posi-
Gallo O. et all (21) investigated in tients with evident infiltration of lym- tive cells, but their number is also in-
88 patients with squamous cell car- phocytes and plasma cells, according creased in the peritumour area. This
cinoma of the larynx intratumoral to their ability to present antigens to process is associated with stroma APC
and peritumoral infiltration of T-zone sensitized T cells. The results indicate migration, potentially inducing an an-
histiocytes, mainly of mature Langer- that the presence of high or intermedi- titumour immune response. n
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