ANTI-AGEING Epidermis Dermis Subcutis
340 330 320 310 300 290 280
Figure 6: Ultrasound image of photoaged skin: presence of a subepidermal low-echogenic band (SLEB) located below the epidermal entrance echo
surface hyaluronate receptor. Changes in the dermis associated with ageing can be detected by skin ultrasonography. In 1989, some authors described a low-
echogenic band-like structure, termed a subepidermal low-echogenic band (SLEB), located immediately below the epidermal entrance echo of photoaged skin. Following this observation, SLEB has been
further described as related to chronic UVR exposure in several studies. In addition, it has been demonstrated that SLEB echogenicity inversely correlates to chronic UV radiation exposure. Skin-targeted ultrasound is a non-invasive
technique that has been extensively used to evaluate age-related dermal changes, and the presence of a subepidermal low-echogenic band (SLEB) has been related to chronic UVR exposure in several studies. Aged and photoaged skin shows a
subepidermal low echogenic band (SLEB) located immediately below the epidermis which is an ultrasound manifestation of elastosis (Figure 6). There is an association between age
D=0 1.5 10.54% 1 D=0 ■ D=56■ -24%
93
0.5
0 D0 D56
Figures 7 and 8: The group aged between 40 and 60 years experienced the greatest SLEB BAND decrease with an average reduction of 24% at the end of the treatment, and a 10.54% improvement in skin density
and SLEB thickness, being the SLEB band a photoaged-related indicator. Ultrasound images are generated with a 20Mhz probe. The echo-dense tissue is detected and an ultrasound image is generated. Ultrasound scanners correctly detect structures in the dermis. Subcutaneous fat thickness could be
obtained by observing the dermis-hypodermis junction and the muscle fascia. Since SLEB echogenicity is photo age-
related, this study aimed to evaluate, through ultrasound imaging, the effects of Cobioage in skin redensification. The measuring area was on the face
(hemiface active versus hemiface placebo). The measurements were performed on D0 and also D56. The results are shown in Figures 7, 8 and 9. After 56 days, the sub-epidermal density improved by +3.1%.
Conclusion Cobioage exerts a global Skin Exposome Protection. Thanks to its elastin stabilizing effect and its ability to induce collagen synthesis, it is a potent anti-wrinkle,
D=56
redensifying, and firming active ingredient. Its antioxidant capacity and protection
against ROS damage bring Cobioage anti- ageing & photoageing protection and anti- pollution activity. Besides all these properties, Cobioage
improves skin morphology, firmness, and elasticity, decreasing the SLEB band and improving the sub-epidermal density. Cobioage brings a broad spectrum of action, giving cosmetic formulas versatile efficacy, essential to meet the current demand presented by the skin ageing exposome.
References 1. Krutmann J, Bouloc A, Sore G, Bernard BA, Passeron T. The skin ageing exposome. J. Dermatol. Sci. 2017 Mar;85(3):152-161
2. Nichols JA, Katiyar SK. Skin photoprotection by natural polyphenols: Anti-inflammatory, anti-oxidant, and DNA repair mechanisms. Arch. Dermatol. Res. 2010 Mar;302(2):71-83
3. Skowyra M, Falguera V, Gallego G, Peiró P, Almajano MP. Antioxidant properties of aqueous and ethanolic extracts of Tara (Caesalpinia spinosa) pods in vitro and in model food emulsions. Journal of the Science of Food and Agriculture. August 2013
4. Lacarrubba F, Tedeschi A, Nardone B, Micali G. Mesotherapy for skin rejuvenation: assessment of the subepidermal low- echogenic band by ultrasound evaluation with cross-sectional B-mode scanning. Dermatol. Ther. Nov-Dec 2008;21 Suppl 3:S1-5
5. Matsubara A, Liang Z, Sato Y, Uchikawa K. Analysis of human perception of facial skin radiance by means of image histogram parameters of surface and subsurface reflections from the skin. Skin Res. Technol. 2012 Aug;18(3):265-71
SLEB Band SLEB Band
Figure 9: Ultrasonography images of a volunteer malar area at the beginning and at the end of the treatment, showing a decrease in the SLEB band as there is an improvement in the sub-epidermal density and therefore an improve in the skin morphology
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6. Nkengne A, Roure R, Rossi AB, Bertin C. The skin ageing index: a new approach for documenting anti-ageing products or procedures. Skin Res. Technol. 2013 Aug;19(3):291-8
7. Narins RS, Carruthers J, Flynn TC, Geister TL. Görtelmeyer R, Hardas B, Himmrich S et al. Validated assessment scales for the lower face. Dermatol. Surg. 2012 Feb;38(2 Spec No.):333-42
September 2022 PERSONAL CARE
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Epidermis
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