32 MARINE INGREDIENTS
Harnessing marine organic osmolytes for better ageing
Dr Juan Pablo De la Roche, Arancha Barata, María R. De Mora, Irene Cordón - Microalgae Solutions
Marine life extends beyond the ocean waters, on the rocky coastline. A living marine micro-ecosystem develops on this hard substrate (epilithic), capable of adapting and molding its beauty to the rhythm of the changing tides. Composed by species of microalgae and associated bacteria (microbiota), this microecosystem, which we call the epilithic holobiont, is of vital importance because it sustains the life of other organisms living on the rocky shore, providing them with food, refuge and protection. For almost 12 hours a day at low tide, this
micro-ecosystem is subjected to high solar radiation, extreme dryness and hypersalinity. With less than 10% water this fascinating microecosystem is able to survive, thanks to the mutual cooperation between these microorganisms, maintaining the cellular osmotic balance with its natural environment. Microalgal and bacterial cells are required,
in principle, to maintain an intracellular osmotic pressure higher than that of the external medium in order to generate cell turgor, generally considered to be the driving force for cell extension, growth and division.1 The production of low molecular weight
molecules, called organic osmolytes or compatible solutes, by these microorganisms
PERSONAL CARE September 2022
is one of the adaptive manifestations to achieve osmoregulation. Thus, there is a flow of osmolytic substances between phytoplankton and bacteria outside the cells in the phycosphere, an intimate site of metabolite exchange (Figure 1).2 The compatible solute answer to the
problem of elevated osmolarity involves a dramatic increase of the production of these osmoprotective compounds given their compatibility with cellular functions at high internal concentrations. For this reason, they are often referred to as compatible solutes.1 Organic osmolytes are molecules which
are compatible with cell metabolism even at molar concentrations and play protective roles in adaptation to extreme environments. These molecules have shown significant effects on biomolecules as stabilisers of native macromolecules (proteins or nucleic acid structures) and antioxidant protection. Organic osmolytes such as free amino acids, DMSP, polyols, i.e. glycerol, and saccharides have been identified in epilithic holobiont.3
Regulators mechanism on skin water homeostasis Like epilithic holobionts, human skin has mechanisms to maintain cellular water homeostasis. It is a fundamental process that
ABSTRACT
Marine life extends beyond the ocean waters to the rocky coastline. A living marine micro-ecosystem develops on this hard substrate: the epilithic holobiont. This supra-organism composed of phytoplankton and its microbiota is a source of natural organic moisturisers. By applying Phycosphere Biodynamic® Technology we biomimic the extreme environment where this holobiont lives. The organic osmolyte-rich extract is extracted to create Osmocean Phycoskin®, an original moisturising and dermoprotective bioactive ingredient reduces the impact of photoageing and restores the skin's natural well-ageing.
is vital for key functions such as cell growth and metabolism on human skin. Therefore, the skin must constantly balance water loss and hydration maintenance, as water levels are vital for maintaining structural integrity, i.e. cell volume, barrier function and immune defense, which impacts the healthy appearance of the skin.4 The skin has several molecules and mechanisms to maintain cellular water
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